ArticleCirculation research2011
The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction.
Article in Circulation research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 69 citations in OpenAlex.
- Stimulatory Effects of Mesenchymal Stem Cells on cKit+ Cardiac Stem Cells Are Mediated by SDF1/CXCR4 and SCF/cKit Signaling Pathways.Circulation research · 2016Trial
- EPHA2-Ephrin-B1 cis-interaction drives an oncogenic reverse signaling, leading to the recurrence of oral cancer.Cell communication and signaling : CCS · 2026Article
- From dried bear bile to molecular investigation of differential effects of bile acids inBrain, behavior, & immunity - health · 2023Review
- The arrhythmogenic cardiomyopathy-specific coding and non-coding transcriptome in human cardiac stromal cells.BMC genomics · 2018Article
- Decline in cellular function of aged mouse c-kitThe Journal of physiology · 2017Article
- Asymmetry at cell-cell interfaces direct cell sorting, boundary formation, and tissue morphogenesis.Experimental cell research · 2017Review
- Article
- Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair.Stem cell reviews and reports · 2016Review
- The effect of ephrin-A1 on resistance to Photofrin-mediated photodynamic therapy in esophageal squamous cell carcinoma cells.Lasers in medical science · 2015Article
- Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.The Journal of pathology · 2015Article
- Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero.Nature communications · 2015Article
- Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy.Nature communications · 2015Article
- Eph receptor tyrosine kinases in cancer stem cells.Cytokine & growth factor reviews · 2015Review
- Activation of EphA4 and EphB2 Reverse Signaling Restores the Age-Associated Reduction of Self-Renewal, Migration, and Actin Turnover in Human Tendon Stem/Progenitor Cells.Frontiers in aging neuroscience · 2015Article
- Eph receptors and ephrins: therapeutic opportunities.Annual review of pharmacology and toxicology · 2015Review
- Cardiac stem cells: biology and clinical applications.Antioxidants & redox signaling · 2014Review
- Cardiac stem cell niches.Stem cell research · 2014Review
- EphA2-receptor deficiency exacerbates myocardial infarction and reduces survival in hyperglycemic mice.Cardiovascular diabetology · 2014Article
- Point mutations in dimerization motifs of the transmembrane domain stabilize active or inactive state of the EphA2 receptor tyrosine kinase.The Journal of biological chemistry · 2014Article
- Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy.Frontiers in physiology · 2014Article
Corrections and comments
- Retraction · 2018-12-12Concerns/Issues about Data · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Upgrade/Update of Prior Notice(s) ·
- Correction · 2017-01-20Concerns/Issues about Image · Error in Image · Investigation by Company/Institution · Upgrade/Update of Prior Notice(s) ·
- Correction · 2015-12-04Conflict of Interest ·
- Expression of concern · 2018-11-20Concerns/Issues about Data · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Updated to Retraction ·
- Erratum issuedCorrection.2015
- Erratum issuedCorrection.2017
- Expression of concern
- Expression of concern
- Retracted
Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleUnderstanding the mechanisms that regulate trafficking of human cardiac stem cells (hCSCs) may lead to development of new therapeutic approaches for the failing heart.
objectiveWe tested whether the motility of hCSCs in immunosuppressed infarcted animals is controlled by the guidance system that involves the interaction of Eph receptors with ephrin ligands. METHODS AND
resultsWithin the cardiac niches, cardiomyocytes expressed preferentially the ephrin A1 ligand, whereas hCSCs possessed the EphA2 receptor. Treatment of hCSCs with ephrin A1 resulted in the rapid internalization of the ephrin A1-EphA2 complex, posttranslational modifications of Src kinases, and morphological changes consistent with the acquisition of a motile cell phenotype. Ephrin A1 enhanced the motility of hCSCs in vitro, and their migration in vivo following acute myocardial infarction. At 2 weeks after infarction, the volume of the regenerated myocardium was 2-fold larger in animals injected with ephrin A1-activated hCSCs than in animals receiving control hCSCs; this difference was dictated by a greater number of newly formed cardiomyocytes and coronary vessels. The increased recovery in myocardial mass with ephrin A1-treated hCSCs was characterized by further restoration of cardiac function and by a reduction in arrhythmic events.
conclusionsEphrin A1 promotes the motility of EphA2-positive hCSCs, facilitates their migration to the area of damage, and enhances cardiac repair. Thus, in situ stimulation of resident hCSCs with ephrin A1 or their ex vivo activation before myocardial delivery improves cell targeting to sites of injury, possibly providing a novel strategy for the management of the diseased heart.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.