ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Synapse loss in olfactory local interneurons modifies perception.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 42 citations in OpenAlex.
- Neurons, Nose, and Neurodegenerative Diseases: Olfactory Function and Cognitive Impairment.International journal of molecular sciences · 2023Review
- Internal state affects local neuron function in an early sensory processing center to shape olfactory behavior in Drosophila larvae.Scientific reports · 2022Article
- Clinical significance of the cognition-related pathogenic proteins in plasma neuronal-derived exosomes among normal cognitive adults over 45 years old with olfactory dysfunction.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Endocannabinoid-mediated neuromodulation in the main olfactory bulb at the interface of environmental stimuli and central neural processing.The European journal of neuroscience · 2022Review
- The Olfactory System as Marker of Neurodegeneration in Aging, Neurological and Neuropsychiatric Disorders.International journal of environmental research and public health · 2021Review
- Neuron-Specific FMRP Roles in Experience-Dependent Remodeling of Olfactory Brain Innervation during an Early-Life Critical Period.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposit formation.Molecular biology of the cell · 2020Article
- Activity-Dependent Synaptic Plasticity inFrontiers in physiology · 2020Review
- Activity-Dependent Remodeling ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Contribution of the GABAergic System to Non-Motor Manifestations in Premotor and Early Stages of Parkinson's Disease.Frontiers in pharmacology · 2019Review
- Temporally specific engagement of distinct neuronal circuits regulating olfactory habituation ineLife · 2018Article
- A GAL80 Collection To Inhibit GAL4 Transgenes inG3 (Bethesda, Md.) · 2018Article
- Neuronal NOS Induces Neuronal Differentiation Through a PKCα-Dependent GSK3β Inactivation Pathway in Hippocampal Neural Progenitor Cells.Molecular neurobiology · 2017Article
- The equilibrium between antagonistic signaling pathways determines the number of synapses in Drosophila.PloS one · 2017Article
- Developmental experience-dependent plasticity in the first synapse of the Drosophila olfactory circuit.Journal of neurophysiology · 2016Review
- Synaptic circuitry of identified neurons in the antennal lobe of Drosophila melanogaster.The Journal of comparative neurology · 2016Article
- Development of connectivity in a motoneuronal network in Drosophila larvae.Current biology : CB · 2015Article
- Article
- Synaptic organization of the Drosophila antennal lobe and its regulation by the Teneurins.eLife · 2014Article
- Insulin signaling regulates neurite growth during metamorphic neuronal remodeling.Biology open · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synapse loss correlates with cognitive decline in aging and most neurological pathologies. Sensory perception changes often represent subtle dysfunctions that precede the onset of a neurodegenerative disease. However, a cause-effect relationship between synapse loss and sensory perception deficits is difficult to prove and quantify due to functional and structural adaptation of neural systems. Here we modified a PI3K/AKT/GSK3 signaling pathway to reduce the number of synapses--without affecting the number of cells--in five subsets of local interneurons of the Drosophila olfactory glomeruli and measured the behavioral effects on olfactory perception. The neuron subsets were chosen under the criteria of GABA or ChAT expression. The reduction of one subset of synapses, mostly inhibitory, converted the responses to all odorants and concentrations tested as repulsive, while the reduction of another subset, mostly excitatory, led to a shift toward attraction. However, the simultaneous reduction of both synapse subsets restored normal perception. One group of local interneurons proved unaffected by the induced synapse loss in the perception of some odorants, indicating a functional specialization of these cells. Using genetic tools for space and temporal control of synapse number decrease, we show that the perception effects are specific to the local interneurons, rather than the mushroom bodies, and are not based on major structural changes elicited during development. These findings demonstrate that synapse loss cause sensory perception changes and suggest that normal perception is based on a balance between excitation and inhibition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.