ArticleBioorganic & medicinal chemistry letters2011
Asymmetric total synthesis of (+)- and (-)-clusianone and (+)- and (-)-clusianone methyl enol ether via ACC alkylation and evaluation of their anti-HIV activity.
Article in Bioorganic & medicinal chemistry letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Total Synthesis of Hypersampsone M.Journal of the American Chemical Society · 2024Article
- Accelerated Clearance and Degradation of Cell-Free HIV by Neutralizing Antibodies Occurs via FcγRIIb on Liver Sinusoidal Endothelial Cells by Endocytosis.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Programmable meroterpene synthesis.Nature communications · 2020Article
- On the Mechanism of the Asymmetric Aldol Addition of Chiral N-Amino Cyclic Carbamate Hydrazones: Evidence of Non-Curtin-Hammett Behavior.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Virucidal activity of Garcinia parvifolia leaf extracts in animal cell culture.BMC complementary and alternative medicine · 2019Article
- Asymmetric, stereodivergent synthesis of (-)-clusianone utilizing a biomimetic cationic cyclization.Angewandte Chemie (International ed. in English) · 2014Article
- A P212121 polymorph of (+)-clusianone.Acta crystallographica. Section E, Structure reports online · 2013Article
- Redetermination and absolute configuration of (+)-7-epiclusianone.Acta crystallographica. Section E, Structure reports online · 2012Article
- Total synthesis of (±)-7-epi-nemorosone.Organic letters · 2012Article
- Synthetic Efforts Toward [3.3.1] Bridged Bicyclic Phloroglucinol Natural Products.Tetrahedron · 2011Article
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Authors and funding
4 authors.
Funding
Abstract
The total asymmetric synthesis of (+)- and (-)-clusianone and (+)- and (-)-clusianone methyl enol ether is reported. Asymmetric induction is achieved through the use of ACC alkylation, providing the key intermediates with an er of 99:1. The four synthetic compounds were evaluated for their anti-HIV activity. Both (+)- and (-)-clusianone displayed significant anti-HIV activity.
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