SynthesisProgress in cardiovascular diseases
Gene-air pollution interaction and cardiovascular disease: a review.
Synthesis in Progress in cardiovascular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 96 citations in OpenAlex.
- Acute exposure to traffic-related air pollution alters antioxidant status in healthy adults.Environmental research · 2020Trial
- Extracellular vesicle-enriched microRNAs interact in the association between long-term particulate matter and blood pressure in elderly men.Environmental research · 2018Trial
- Pretreatment with Antioxidants Augments the Acute Arterial Vasoconstriction Caused by Diesel Exhaust Inhalation.American journal of respiratory and critical care medicine · 2016Trial
- Gene-Air Pollution Interaction in Cardiovascular Disease: Lights and Shadows in a Tangled Risk Factor Network.International journal of molecular sciences · 2026Review
- Long-Term Exposure to Ambient Air Pollution and Metabolic Syndrome and Its Components.Journal of obesity & metabolic syndrome · 2025Review
- Exposure to Air Pollutants and Myocardial Infarction Incidence: A UK Biobank Study Exploring Gene-Environment Interaction.Environmental health perspectives · 2024Article
- Causal associations of particulate matter 2.5 and cardiovascular disease: A two-sample mendelian randomization study.PloS one · 2024Article
- Outdoor artificial light at night, air pollution, and risk of childhood acute lymphoblastic leukemia in the California Linkage Study of Early-Onset Cancers.Scientific reports · 2023Article
- Ecological study of ambient air pollution exposure and mortality of cardiovascular diseases in elderly.Scientific reports · 2022Article
- Spike in pollution to ignite the bursting of COVID-19 second wave is more dangerous than spike of SAR-CoV-2 under environmental ignorance in long term: a review.Environmental science and pollution research international · 2022Review
- Associations between APOL1 genetic variants and blood pressure in African American mothers and children from a U.S. pregnancy cohort: Modification by air pollution exposures.Environmental research · 2022Article
- Air pollution and biomarkers of cardiovascular disease and inflammation in the Malmö Diet and Cancer cohort.Environmental health : a global access science source · 2022Article
- The effects of gene × environment interactions on silver nanoparticle toxicity in the respiratory system: An adverse outcome pathway.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Inverse probability weighted distributed lag effects of short-term exposure to PMEnvironmental research · 2020Article
- A review of gene-by-air pollution interactions for cardiovascular disease, risk factors, and biomarkers.Human genetics · 2019Review
- Meta-Analysis ofToxics · 2018Article
- Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution: Part 3 of a 3-Part Series.Journal of the American College of Cardiology · 2017Review
- Chemical Risk Assessment: Traditional vs Public Health Perspectives.American journal of public health · 2017Article
- Moving beyond regression techniques in cardiovascular risk prediction: applying machine learning to address analytic challenges.European heart journal · 2017Review
- COX-2 mediates PM2.5-induced apoptosis and inflammation in vascular endothelial cells.American journal of translational research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Genetic susceptibility is likely to play a role in response to air pollution. Hence, gene-environment interaction studies can be a tool for exploring the mechanisms and the importance of the pathway in the association between air pollution and a cardiovascular outcome. In this article, we present a systematic review of the studies that have examined gene-environment interactions in relation to the cardiovascular health effects of air pollutants. We identified 16 articles meeting our search criteria. Of these studies, most have focused on individual functional polymorphisms or individual candidate genes. Moreover, they were all based on 3 study populations that have been extensively investigated in relation to air pollution effects: the Normative Aging Study, Air Pollution and Inflammatory Response in Myocardial Infarction Survivors: Gene-Environment Interaction in a High Risk Group, and Multiethnic Study of Atherosclerosis. In conclusions, the studies differed substantially in both the cardiovascular outcomes examined and the polymorphisms examined, so there is little confirmation of results across cohorts. Gene-environment interaction studies can help explore the mechanisms and the potential pathway in the association between air pollution and a cardiovascular outcome; replication of findings and studies involving multiple cohorts would be needed to draw stronger conclusions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.