Evidence map›Paper›PMID 21414317›Full record

ReviewFEBS letters2011

Circadian disruption and SCN control of energy metabolism.

Andries Kalsbeek, Frank A Scheer, Stephanie Perreau-Lenz, Susanne E La Fleur, Chun-Xia Yi, Eric Fliers, Ruud M Buijs

Abstract readReview
In one paragraph

Review in FEBS letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Sleep disorders in hepatocellular carcinoma.World journal of gastrointestinal oncology · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Artificial Light at Night and Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2024
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Andries KalsbeekDepartment of Endocrinology and Metabolism, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands. a.kalsbeek@amc.uva.nl
Frank A Scheer
Stephanie Perreau-Lenz
Susanne E La Fleur
Chun-Xia Yi
Eric Fliers
Ruud M Buijs
Netherlands Institute for Neuroscience · NLAcademic Medical Center · NLBrigham and Women's Hospital · USCentral Institute of Mental Health · DEUniversidad Nacional Autónoma de México · MXUniversity of Amsterdam · NL

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Mechanisms underlying adverse health consequences of shift workR01HL094806 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2009 to 2013
$1.6M
New Faculty in Sleep MedicineP30HL101299 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A · 2009 to 2010
$733k
NCRR NIH HHS UL1 RR025758NHLBI NIH HHS P30 HL101299NHLBI NIH HHS P30HL101299NHLBI NIH HHS R01 HL094806NHLBI NIH HHS R01HL094806
6 · The paper itself

Abstract

In this review we first present the anatomical pathways used by the suprachiasmatic nuclei to enforce its rhythmicity onto the body, especially its energy homeostatic system. The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not only ensures that we wake up on time, but also that our glucose metabolism and cardiovascular system are prepared for increased activity. The drawback of such a highly integrated system, however, becomes visible when our daily lives are not fully synchronized with the environment. Thus, in addition to increased physical activity and decreased intake of high-energy food, also a well-lighted and fully resonating biological clock may help to withstand the increasing "diabetogenic" pressure of today's 24/7 society.

Indexed as

Adipose TissueAnimalsAutonomic Nervous SystemCircadian RhythmEnergy MetabolismHormonesHumansSuprachiasmatic NucleusHormones

Identifiers

PMID21414317
PMCPMC3095769
OpenAlexW2065239869

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.