ArticleBMC genomics2011
Rhythms and synchronization patterns in gene expression in the Aedes aegypti mosquito.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed.
- Time-of-day changes in permethrin susceptibility and metabolic gene expression in Florida Aedes aegypti (Diptera: Culicidae).Journal of medical entomology · 2025Article
- Circadian and daily rhythms of disease vector mosquitoes.Current opinion in insect science · 2024Review
- Circadian regulation of dengue virus transmission and replication: insights into vector activity and viral dynamics.Frontiers in cellular and infection microbiology · 2024Review
- Time-series analysis of transcriptomic changes due to permethrin exposure reveals that Aedes aegypti undergoes detoxification metabolism over 24 h.Scientific reports · 2023Article
- Light and dark cycles modify the expression of clock genes in the ovaries of Aedes aegypti in a noncircadian manner.PloS one · 2023Article
- Molecular Oscillator Affects Susceptibility of Caterpillars to Insecticides: Studies on the Egyptian Cotton Leaf Worm-Insects · 2022Article
- A transcriptomic atlas ofeLife · 2022Article
- Regulation of the antennal transcriptome of the dengue vector, Aedes aegypti, during the first gonotrophic cycle.BMC genomics · 2021Article
- The Summer Is Coming:Frontiers in physiology · 2020Article
- Article
- Diapause and quiescence: dormancy mechanisms that contribute to the geographical expansion of mosquitoes and their evolutionary success.Parasites & vectors · 2017Review
- Article
- Meta-Analysis ofFrontiers in bioengineering and biotechnology · 2017Article
- Review
- Contrasting genetic structure between mitochondrial and nuclear markers in the dengue fever mosquito from Rio de Janeiro: implications for vector control.Evolutionary applications · 2015Article
- Global transcriptional dynamics of diapause induction in non-blood-fed and blood-fed Aedes albopictus.PLoS neglected tropical diseases · 2015Article
- Functional circadian clock genes are essential for the overwintering diapause of the Northern house mosquito, Culex pipiens.The Journal of experimental biology · 2015Article
- "The Environment is Everything That Isn't Me": Molecular Mechanisms and Evolutionary Dynamics of Insect Clocks in Variable Surroundings.Frontiers in physiology · 2015Review
- Article
- A database of circadian and diel rhythmic gene expression in the yellow fever mosquito Aedes aegypti.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAedes aegypti is arguably the most studied of all mosquito species in the laboratory and is the primary vector of both Dengue and Yellow Fever flaviviruses in the field. A large number of transcriptional studies have been made in the species and these usually report transcript quantities observed at a certain age or stage of development. However, circadian oscillation is an important characteristic of gene expression in many animals and plants, modulating both their physiology and behavior. Circadian gene expression in mosquito species has been previously reported but for only a few genes directly involved in the function of the molecular clock.
resultsHerein we analyze the transcription profiles of 21,494 messenger RNAs using an Ae. aegypti Agilent® microarray. Transcripts were quantified in adult female heads at 24 hours and then again at 72 hours and eight subsequent time points spaced four hours apart. We document circadian rhythms in multiple molecular pathways essential for growth, development, immune response, detoxification/pesticide resistance. Circadian rhythms were also noted in ribosomal protein genes used for normalization in reverse transcribed PCR (RT-PCR) to determine transcript abundance. We report pervasive oscillations and intricate synchronization patterns relevant to all known biological pathways.
conclusionThese results argue strongly that transcriptional analyses either need to be made over time periods rather than confining analyses to a single time point or development stage or exceptional care needs to be made to synchronize all mosquitoes to be analyzed and compared among treatment groups.
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