ArticleVeterinary research2011
Genome sequence of Helicobacter suis supports its role in gastric pathology.
Article in Veterinary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 73 citations in OpenAlex.
- Indication and identification ofOpen veterinary journal · 2025Article
- Gastric Helicobacter species associated with dogs, cats and pigs: significance for public and animal health.Veterinary research · 2022Review
- Isolation and characterization ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Role ofJournal of clinical medicine · 2020Review
- Distinct transcriptome signatures of Helicobacter suis and Helicobacter heilmannii strains upon adherence to human gastric epithelial cells.Veterinary research · 2020Article
- Complete Genome Sequence of Helicobacter suis Strain SNTW101c, Originally Isolated from a Patient with Nodular Gastritis.Microbiology resource announcements · 2020Article
- Helicobacter suis binding to carbohydrates on human and porcine gastric mucins and glycolipids occurs via two modes.Virulence · 2018Article
- In silico proteomic and phylogenetic analysis of the outer membrane protein repertoire of gastric Helicobacter species.Scientific reports · 2018Article
- Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence.The ISME journal · 2018Article
- Phylogeographic diversity and mosaicism of theMobile DNA · 2018Article
- Cloning of Helicobacter suis cholesterol α-glucosyltransferase and production of an antibody capable of detecting it in formalin-fixed, paraffin-embedded gastric tissue sections.Histochemistry and cell biology · 2017Article
- Characterization of the Cag pathogenicity island in Helicobacter pylori from naturally infected rhesus macaques.FEMS microbiology letters · 2016Article
- Draft Genome Sequence of Helicobacter suis Strain SNTW101, Isolated from a Japanese Patient with Nodular Gastritis.Genome announcements · 2016Article
- Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma.Helicobacter · 2016Article
- Oral glutathione supplementation drastically reduces Helicobacter-induced gastric pathologies.Scientific reports · 2016Article
- Role of γ-glutamyltranspeptidase in the pathogenesis of Helicobacter suis and Helicobacter pylori infections.Veterinary research · 2015Article
- Helicobacter heilmannii sensu lato: an overview of the infection in humans.World journal of gastroenterology · 2014Review
- Gastric de novo Muc13 expression and spasmolytic polypeptide-expressing metaplasia during Helicobacter heilmannii infection.Infection and immunity · 2014Article
- A comprehensive analysis of Helicobacter pylori plasticity zones reveals that they are integrating conjugative elements with intermediate integration specificity.BMC genomics · 2014Article
- Role of Campylobacter jejuni gamma-glutamyl transpeptidase on epithelial cell apoptosis and lymphocyte proliferation.Gut pathogens · 2014Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter (H.) suis has been associated with chronic gastritis and ulcers of the pars oesophagea in pigs, and with gastritis, peptic ulcer disease and gastric mucosa-associated lymphoid tissue lymphoma in humans. In order to obtain better insight into the genes involved in pathogenicity and in the specific adaptation to the gastric environment of H. suis, a genome analysis was performed of two H. suis strains isolated from the gastric mucosa of swine. Homologs of the vast majority of genes shown to be important for gastric colonization of the human pathogen H. pylori were detected in the H. suis genome. H. suis encodes several putative outer membrane proteins, of which two similar to the H. pylori adhesins HpaA and HorB. H. suis harbours an almost complete comB type IV secretion system and members of the type IV secretion system 3, but lacks most of the genes present in the cag pathogenicity island of H. pylori. Homologs of genes encoding the H. pylori neutrophil-activating protein and γ-glutamyl transpeptidase were identified in H. suis. H. suis also possesses several other presumptive virulence-associated genes, including homologs for mviN, the H. pylori flavodoxin gene, and a homolog of the H. pylori vacuolating cytotoxin A gene. It was concluded that although genes coding for some important virulence factors in H. pylori, such as the cytotoxin-associated protein (CagA), are not detected in the H. suis genome, homologs of other genes associated with colonization and virulence of H. pylori and other bacteria are present.
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