Trial reportJournal of palliative medicine2011
Effects of a problem-solving intervention (COPE) on quality of life for patients with advanced cancer on clinical trials and their caregivers: simultaneous care educational intervention (SCEI): linking palliation and clinical trials.
Trial report in Journal of palliative medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 12 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Interventions to improve outcomes for caregivers of patients with advanced cancer: a meta-analysis.Journal of the National Cancer Institute · 2023Pooled it
- A meta-analysis of the effects of cognitive behavioral therapy on quality of life and negative emotions of informal cancer caregivers.Frontiers in psychiatry · 2022Pooled it
- Effects of psychosocial interventions on psychological outcomes among caregivers of advanced cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Pooled it
- A systematic review of psychosocial interventions to improve quality of life of people with cancer and their family caregivers.Nursing open · 2020Pooled it
- Association between dyadic interventions and outcomes in cancer patients: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Pooled it
- Multicomponent Palliative Care Interventions in Advanced Chronic Diseases: A Systematic Review.The American journal of hospice & palliative care · 2018Pooled it
- Early palliative care for adults with advanced cancer.The Cochrane database of systematic reviews · 2017Pooled it
- Controlled rehabilitative and supportive care intervention trials in patients with high-grade gliomas and their caregivers: a systematic review.BMJ supportive & palliative care · 2016Pooled it
- Psychometric properties of carer-reported outcome measures in palliative care: A systematic review.Palliative medicine · 2016Pooled it
- Effectiveness of family and caregiver interventions on patient outcomes in adults with cancer: a systematic review.Journal of general internal medicine · 2014Pooled it
- Methods for improving the quality of palliative care delivery: a systematic review.The American journal of hospice & palliative care · 2014Pooled it
- A systematic review of cognitive behavioral interventions in advanced cancer.Patient education and counseling · 2012Pooled it
- A Mobile Instant Messaging-Delivered Psychoeducational Intervention for Cancer Caregivers: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Outcomes of a Problem-Solving Medication Management Intervention for Informal Caregivers.Western journal of nursing research · 2019Trial
- Does it matter what you call it? A randomized trial of language used to describe palliative care services.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Trial
- Enhancing quality of life and mastery of informal caregivers of high-grade glioma patients: a randomized controlled trial.Journal of neuro-oncology · 2013Trial
- Advancing Prostate Cancer Survivorship through Transatlantic Consortium Science: The iCCaRE Initiative.Cancer research communications · 2026Article
- Use of supportive care services and advance care planning among early phase oncology clinical trial participants.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Positive Psychology Approaches to Interventions for Cancer Dyads: A Scoping Review.International journal of environmental research and public health · 2022Article
- Incorporating palliative care principles to improve patient care and quality of life in urologic oncology.Nature reviews. Urology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
contextPatients on investigational clinical trials and their caregivers experience poor quality of life (QOL), which declines as the disease progresses.
objectiveTo examine the effect of a standardized cognitive-behavioral problem-solving educational intervention on the QOL of patients enrolled on investigational clinical trials and their caregivers.
designProspective, multi-institution, randomized trial. QOL was measured repeatedly over 6 months.
participantsPatients were simultaneously enrolled onto phase 1, 2, or 3 Institutional Review Board (IRB)-approved cancer clinical trials.
interventionIntervention arm dyads participated in three conjoint educational sessions during the first month, learning the COPE problem solving model. Nonintervention arm dyads received usual care. OUTCOME MEASURES: Global QOL was measured by the City of Hope Quality of Life Instruments for Patients or Caregivers; problem solving skills were measured by the Social Problem Solving Inventory-Revised.
resultsThe results are reported using the CONSORT statement. The analytic data set included 476 dyads including 1596 patient data points and 1576 care giver data points. Patient QOL showed no significant difference in the rate of change between the intervention and usual care arms (p = 0.70). Caregiver QOL scores in the intervention arm declined, but at less than half the rate in the control arm (p = 0.02).
conclusionsThe COPE intervention enabled the average caregiver to come much closer to stable QOL over the 6-month follow-up. Future studies should enroll subjects much earlier in the cancer illness trajectory, a common patient/caregiver theme. The maximum effect was seen in caregivers who completed the 6-month follow-up, suggesting that the impact may increase over time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.