ArticleJournal of the American Chemical Society2011
A modular system for the synthesis of multiplexed magnetic resonance probes.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
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- Large Protein Assemblies for High-Relaxivity Contrast Agents: The Case of Gadolinium-Labeled Asparaginase.Bioconjugate chemistry · 2022Article
- Non-metallic TNature communications · 2022Article
- An NMR relaxometry approach for quantitative investigation of the transchelation of gadolinium ions from GBCAs to a competing macromolecular chelator.Scientific reports · 2021Article
- Rigid and Compact Binuclear Bis-hydrated Gd-complexes as High Relaxivity MRI Agents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Revisiting paramagnetic relaxation enhancements in slowly rotating systems: how long is the long range?Magnetic resonance (Gottingen, Germany) · 2021Article
- Applications for Transition-Metal Chemistry in Contrast-Enhanced Magnetic Resonance Imaging.Inorganic chemistry · 2020Review
- A Ln(III)-3-hydroxypyridine pH responsive probe optimized by DFT.RSC advances · 2020Article
- Water-Soluble Nanoconjugate for Enhanced Cellular Delivery of Receptor-Targeted Magnetic Resonance Contrast Agents.Bioconjugate chemistry · 2019Article
- Bimodal Fluorescence-Magnetic Resonance Contrast Agent for Apoptosis Imaging.Journal of the American Chemical Society · 2019Article
- Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chemical reviews · 2019Review
- Optimization of ZD2 Peptide Targeted Gd(HP-DO3A) for Detection and Risk-Stratification of Prostate Cancer with MRI.ACS medicinal chemistry letters · 2018Article
- Building a Better Magnetic Resonance Imaging Contrast Agent Using Macromolecular Architecture.ACS central science · 2017Article
- Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors.ACS central science · 2017Article
- Optimizing the Readout of Lanthanide-DOTA Complexes for the Detection of Ligand-Bound Copper(I).Molecules (Basel, Switzerland) · 2017Article
- Targeted Contrast Agent Specific to an Oncoprotein in Tumor Microenvironment with the Potential for Detection and Risk Stratification of Prostate Cancer with MRI.Bioconjugate chemistry · 2017Article
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6 authors.
Funding
Abstract
We have developed a modular architecture for preparing high-relaxivity multiplexed probes utilizing click chemistry. Our system incorporates azide bearing Gd(III) chelates and a trialkyne scaffold with a functional group for subsequent modification. In optimizing the relaxivity of this new complex, we undertook a study of the linker length between a chelate and the scaffold to determine its effect on relaxivity. The results show a strong dependence on flexibility between the individual chelates and the scaffold with decreasing linker length leading to significant increases in relaxivity. Nuclear magnetic resonance dispersion (NMRD) spectra were obtained to confirm a 10-fold increase in the rotational correlation time from 0.049 to 0.60 ns at 310 K. We have additionally obtained a crystal structure demonstrating that modification with an azide does not impact the coordination of the lanthanide. The resulting multinuclear center has a 500% increase in per Gd (or ionic) relaxivity at 1.41 T versus small molecule contrast agents and a 170% increase in relaxivity at 9.4 T.
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