ArticleGenesis (New York, N.Y. : 2000)2011
Generation of mice with a conditional allele for the p75(NTR) neurotrophin receptor gene.
Article in Genesis (New York, N.Y. : 2000), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- CD271 orchestrates skin structure, differentiation, and inflammation via PI3K/Akt and PKCα/ERK pathways.Cell death & disease · 2025Article
- p75NTR modulation prevents cellular, cortical activity and cognitive dysfunctions caused by perinatal hypoxia.Brain : a journal of neurology · 2025Article
- Redundancy of p75NTR neurotrophin receptor function in development, growth and fertility in the rat.Transgenic research · 2024Article
- CD271 mRNA/hnRNPA2B1 complex promotes proliferation and stemness in oral and head and neck squamous cell carcinoma.Cancer science · 2024Article
- Nerve growth factor receptor limits inflammation to promote remodeling and repair of osteoarthritic joints.Nature communications · 2024Article
- Nerve Growth Factor Receptor Limits Inflammation to Promote Remodeling and Repair of Osteoarthritic Joints.bioRxiv : the preprint server for biology · 2023Article
- Excess cerebellar granule neurons induced by the absence of p75NTR during development elicit social behavior deficits in mice.Frontiers in molecular neuroscience · 2023Article
- Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties.Stem cells international · 2023Review
- Article
- Sexual Dimorphism in Balance and Coordination in p75NTRFrontiers in behavioral neuroscience · 2022Article
- Metabolic Control of Sensory Neuron Survival by the p75 Neurotrophin Receptor in Schwann Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention.Communications biology · 2021Article
- Cell non-autonomous requirement of p75 in the development of geniculate oral sensory neurons.Scientific reports · 2020Article
- The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation.eLife · 2020Article
- Exposure to small molecule cocktails allows induction of neural crest lineage cells from human adipose-derived mesenchymal stem cells.PloS one · 2020Article
- The p75NTR Influences Cerebellar Circuit Development and Adult Behavior via Regulation of Cell Cycle Duration of Granule Cell Progenitors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The p75 Neurotrophin Receptor Is an Essential Mediator of Impairments in Hippocampal-Dependent Associative Plasticity and Memory Induced by Sleep Deprivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- p75 Neurotrophin Receptor Activation Regulates the Timing of the Maturation of Cortical Parvalbumin Interneuron Connectivity and Promotes Juvenile-like Plasticity in Adult Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Peripheral Nerve Regeneration Is Independent From Schwann Cell p75Frontiers in cellular neuroscience · 2019Article
- Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons.The Journal of cell biology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The p75(NTR) neurotrophin receptor has been implicated in multiple biological and pathological processes. While significant advances have recently been made in understanding the physiologic role of p75(NTR) , many details and aspects remain to be determined. This is in part because the two existing knockout mouse models (Exons 3 or 4 deleted, respectively), both display features that defy definitive conclusions. Here we describe the generation of mice that carry a conditional p75(NTR) (p75(NTR-FX) ) allele made by flanking Exons 4-6, which encode the transmembrane and all cytoplasmic domains, by loxP sites. To validate this novel conditional allele, both neural crest-specific p75(NTR) /Wnt1-Cre mutants and conventional p75(NTR) null mutants were generated. Both mutants displayed abnormal hind limb reflexes, implying that loss of p75(NTR) in neural crest-derived cells causes a peripheral neuropathy similar to that seen in conventional p75(NTR) mutants. This novel conditional p75(NTR) allele will offer new opportunities to investigate the role of p75(NTR) in specific tissues and cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.