ArticleInternational journal of cancer2012
Adult weight change and incidence of premenopausal breast cancer.
Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- The effect of body mass index change on breast and uterine cancer risk in middle- and older-aged adults.International journal of cancer · 2026Article
- Incident Early- and Later-Onset Type 2 Diabetes and Risk of Early- and Later-Onset Cancer: Prospective Cohort Study.Diabetes care · 2023Article
- Obesity and Breast Cancer Risk: The Oncogenic Implications of Metabolic Dysregulation.The Journal of clinical endocrinology and metabolism · 2022Article
- Bariatric Surgery and Breast Cancer Incidence: a Population-Based, Matched Cohort Study.Obesity surgery · 2022Article
- Body size and weight change over adulthood and risk of breast cancer by menopausal and hormone receptor status: a pooled analysis of 20 prospective cohort studies.European journal of epidemiology · 2021Article
- Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women.International journal of cancer · 2020Article
- Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype.Breast cancer research : BCR · 2019Article
- Prospective evaluation of body size and breast cancer risk among BRCA1 and BRCA2 mutation carriers.International journal of epidemiology · 2018Article
- Weight and weight changes in early adulthood and later breast cancer risk.International journal of cancer · 2017Article
- Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancer.Cancer medicine · 2016Article
- Effects of obesity on hormonally driven cancer in women.Science translational medicine · 2016Review
- Article
- Does obesity have detrimental effects on IVF treatment outcomes?BMC women's health · 2015Article
- Risk Factors for Premenopausal Breast Cancer in Bangladesh.International journal of breast cancer · 2015Article
- Article
- BMI and lifetime changes in BMI and cancer mortality risk.PloS one · 2015Article
- Gene variations in oestrogen pathways, CYP19A1, daily 17β-estradiol and mammographic density phenotypes in premenopausal women.Breast cancer research : BCR · 2014Article
- Risk factors differ between recurrent and incident preeclampsia: a hospital-based cohort study.Annals of epidemiology · 2014Article
- Risk determination and prevention of breast cancer.Breast cancer research : BCR · 2014Review
- Obesity-mediated regulation of HGF/c-Met is associated with reduced basal-like breast cancer latency in parous mice.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Overweight and obesity are inversely related to the risk of breast cancer among premenopausal women. We assessed the association between adult weight change since age 18 years with the risk of breast cancer among premenopausal women to explore whether weight gain was associated with a decrease in risk and weight loss was associated with an increase in risk. A total of 56,223 premenopausal participants in the Nurses' Health Study and 109,385 premenopausal participants in the Nurses' Health Study II were prospectively followed for up to 32 years and 18 years, respectively, and weight change since age 18 years was assessed biennially. The incidence of invasive breast cancer was assessed throughout follow-up. Weight loss of 5 kg or more since age 18, maintained for at least 4 years, was related to lower incidence of premenopausal breast cancer, compared to maintaining a stable weight, but this relation was of borderline statistical significance (covariate-adjusted HR = 0.75; 95% CI 0.52-1.09). Weight gain since age 18 years was also inversely related to breast cancer incidence among premenopausal women (covariate-adjusted p for trend = 0.01), but the association weakened after controlling for weight at age 18 and did not reach statistical significance (p for trend = 0.08). Although obesity and breast cancer among premenopausal women are inversely related, weight loss since age 18 years did not increase and weight gain did not significantly decrease the risk of premenopausal breast cancer among participants in the large prospective cohorts of NHS and NHS II.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.