ArticleMovement disorders : official journal of the Movement Disorder Society2011
Common variants in PARK loci and related genes and Parkinson's disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- White Matter Abnormalities in Patients With Parkinson's Disease: A Meta-Analysis of Diffusion Tensor Imaging Using Tract-Based Spatial Statistics.Frontiers in aging neuroscience · 2020Pooled it
- Exploring the Potential of Biomimetic Peptides in Targeting Fibrillar and Filamentous Alpha-Synuclein-An In Silico and Experimental Approach to Parkinson's Disease.Biomimetics (Basel, Switzerland) · 2024Article
- Haploinsufficiency of the Parkinson's disease gene synaptojanin1 is associated with abnormal responses to psychomotor stimulants and mesolimbic dopamine signaling.Frontiers in behavioral neuroscience · 2024Article
- Genome-wide DNA methylation analysis in schizophrenia with tardive dyskinesia: a preliminary study.Genes & genomics · 2023Article
- Biomarkers in Neurodegenerative Diseases: Proteomics Spotlight on ALS and Parkinson's Disease.International journal of molecular sciences · 2022Review
- A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease.NPJ Parkinson's disease · 2021Review
- Genetics of synucleins in neurodegenerative diseases.Acta neuropathologica · 2021Review
- Rare and novel variants of PRKN and PINK1 genes in Vietnamese patients with early-onset Parkinson's disease.Molecular genetics & genomic medicine · 2020Article
- Epigenetics in Lewy Body Diseases: Impact on Gene Expression, Utility as a Biomarker, and Possibilities for Therapy.International journal of molecular sciences · 2020Review
- A Comprehensive Analysis of the Association BetweenFrontiers in molecular neuroscience · 2018Article
- Genetic Variants in SNCA and the Risk of Sporadic Parkinson's Disease and Clinical Outcomes: A Review.Parkinson's disease · 2017Review
- Analysis of PRKN Variants and Clinical Features in Polish Patients with Parkinson's Disease.Current genomics · 2015Article
- LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration.Scientific reports · 2015Article
- Alpha-synuclein repeat variants and survival in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2014Article
- Does α-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease?Parkinsonism & related disorders · 2014Article
- Rare variants in LRRK1 and Parkinson's disease.Neurogenetics · 2014Article
- Genetic susceptibility loci, environmental exposures, and Parkinson's disease: a case-control study of gene-environment interactions.Parkinsonism & related disorders · 2013Article
- A network view on Parkinson's disease.Computational and structural biotechnology journal · 2013Article
- Manganese homeostasis and transport.Metal ions in life sciences · 2013Article
- LRRK2: cause, risk, and mechanism.Journal of Parkinson's disease · 2013Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Rare mutations in PARK loci genes cause Parkinson's disease (PD) in some families and isolated populations. We investigated the association of common variants in PARK loci and related genes with PD susceptibility and age at onset in an outbred population. A total of 1,103 PD cases from the upper Midwest, USA, were individually matched to unaffected siblings (n = 654) or unrelated controls (n = 449) from the same region. Using a sequencing approach in 25 cases and 25 controls, single nucleotide polymorphisms (SNPs) in species-conserved regions of PARK loci and related genes were detected. We selected additional tag SNPs from the HapMap. We genotyped a total of 235 SNPs and two variable number tandem repeats in the ATP13A2, DJ1, LRRK1, LRRK2, MAPT, Omi/HtrA2, PARK2, PINK1, SNCA, SNCB, SNCG, SPR, and UCHL1 genes in all 2,206 subjects. Case-control analyses were performed to study association with PD susceptibility, while cases-only analyses were used to study association with age at onset. Only MAPT SNP rs2435200 was associated with PD susceptibility after correction for multiple testing (OR = 0.74, 95% CI = 0.64-0.86, uncorrected P < 0.0001, log additive model); however, 16 additional MAPT variants, seven SNCA variants, and one LRRK2, PARK2, and UCHL1 variants each had significant uncorrected P-values. There were no significant associations for age at onset after correction for multiple testing. Our results confirm the association of MAPT and SNCA genes with PD susceptibility but show limited association of other PARK loci and related genes with PD.
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Registered trials
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