ReviewJournal of cellular physiology2012
Systems biology provides new insights into the molecular mechanisms that control the fate of embryonic stem cells.
Review in Journal of cellular physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells.International journal of molecular sciences · 2023Pooled it
- Glutamatergic Neurons Differentiated from Embryonic Stem Cells: An Investigation of Differentiation and Associated Diseases.International journal of molecular sciences · 2021Review
- Sox2: regulation of expression and contribution to brain tumors.CNS oncology · 2016Review
- Sox2 in the differentiation of cochlear progenitor cells.Scientific reports · 2016Article
- Article
- Reprogramming the methylome: erasing memory and creating diversity.Cell stem cell · 2014Article
- Concise review: The Sox2-Oct4 connection: critical players in a much larger interdependent network integrated at multiple levels.Stem cells (Dayton, Ohio) · 2013Review
- Culture of mouse amniotic fluid-derived cells on irradiated STO feeders results in the generation of primitive endoderm cell lines capable of self-renewal in vitro.Cells, tissues, organs · 2013Article
- Differential expression of ID4 and its association with TP53 mutation, SOX2, SOX4 and OCT-4 expression levels.PloS one · 2013Article
- The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.PloS one · 2013Article
- Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Determination of protein interactome of transcription factor Sox2 in embryonic stem cells engineered for inducible expression of four reprogramming factors.The Journal of biological chemistry · 2012Article
- Pluripotent stem cell heterogeneity and the evolving role of proteomic technologies in stem cell biology.Proteomics · 2011Review
- Banf1 is required to maintain the self-renewal of both mouse and human embryonic stem cells.Journal of cell science · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During the last 5 years there has been enormous progress in developing a deeper understanding of the molecular mechanisms that control the self-renewal and pluripotency of embryonic stem cells (ESC). Early progress resulted from studying individual transcription factors and signaling pathways. Unexpectedly, these studies demonstrated that small changes in the levels of master regulators, such as Oct4 and Sox2, promote the differentiation of ESC. More recently, impressive progress has been made using technologies that provide a global view of the signaling pathways and the gene regulatory networks that control the fate of ESC. This review provides an overview of the progress made using several different high-throughput technologies and focuses on proteomic studies, which provide the first glimpse of the protein-protein interaction networks used by ESC. The latter studies indicate that transcription factors required for the self-renewal of ESC are part of a large, highly integrated protein-protein interaction landscape, which helps explain why the levels of master regulators need to be regulated precisely in ESC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.