ArticleJournal of human hypertension2012
Matsuda-DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese: the Tanno-Sobetsu study.
Article in Journal of human hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 25 citations in OpenAlex.
- Association between body roundness index and the prevalence of diffuse idiopathic skeletal hyperostosis in elderly patients: the Bunkyo health study.Scientific reports · 2026Article
- Association of lipid-based insulin resistance indices with rheumatoid arthritis prevalence: a cross-sectional study from NHANES 2007-2018.Clinical rheumatology · 2026Article
- Parboiled Rice and Glycemic Control: Effects on Postprandial Glucose, Insulin Sensitivity, and Incretin Response in Healthy and Type 2 Diabetic Individuals, a Pilot Study.Foods (Basel, Switzerland) · 2025Article
- Bacterial and clinical metabolic signatures and their interactions in obese patients post-bariatric surgery.BMC gastroenterology · 2024Article
- A novel simple disposition index (SPINA-DI) from fasting insulin and glucose concentration as a robust measure of carbohydrate homeostasis.Journal of diabetes · 2024Article
- Continuous glucose monitoring captures glycemic variability in obesity after sleeve gastrectomy: A prospective cohort study.Obesity science & practice · 2024Article
- Adipose tissue insulin resistance predicts the incidence of hypertension: The Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- SPINA Carb: a simple mathematical model supporting fast in-vivo estimation of insulin sensitivity and beta cell function.Scientific reports · 2022Article
- Insulin resistance based on postglucose load measure is associated with prevalence and burden of cerebral small vessel disease.BMJ open diabetes research & care · 2022Article
- Balanced Free Essential Amino Acids and Resistance Exercise Training Synergistically Improve Dexamethasone-Induced Impairments in Muscle Strength, Endurance, and Insulin Sensitivity in Mice.International journal of molecular sciences · 2022Article
- Article
- Prediction of subclinical atherosclerosis in low Framingham risk score individuals by using the metabolic syndrome criteria and insulin sensitivity index.Frontiers in nutrition · 2022Article
- Article
- Efficacy and Safety of Aronia, Red Ginseng, Shiitake Mushroom, and Nattokinase Mixture on Insulin Resistance in Prediabetic Adults: A Randomized, Double-Blinded, Placebo-Controlled Trial.Foods (Basel, Switzerland) · 2021Article
- The cross-sectional association of renal dysfunction with tests of cognition in middle-aged adults with early type 2 diabetes: The GRADE Study.Journal of diabetes and its complications · 2021 · on this mapArticle
- Different pathogenesis of glucose intolerance in two subtypes of primary aldosteronism: Aldosterone-producing adenoma and idiopathic hyperaldosteronism.Journal of diabetes investigation · 2020Article
- Distinct impacts of sleep-disordered breathing on glycemic variability in patients with and without diabetes mellitus.PloS one · 2017Article
- Substantial Inter-Subject Variability in Blood Pressure Responses to Glucose in a Healthy, Non-obese Population.Frontiers in physiology · 2017Article
- Importance of Lean Muscle Maintenance to Improve Insulin Resistance by Body Weight Reduction in Female Patients with Obesity.Diabetes & metabolism journal · 2016Article
- Low alpha-synuclein levels in the blood are associated with insulin resistance.Scientific reports · 2015Observational
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10 authors at 1 institution in 1 country.
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Abstract
Here we examined whether the Matsuda-DeFronzo insulin sensitivity index (ISI-M) is more efficient than the homeostasis model assessment of insulin resistance (HOMA-IR) for assessing risk of hypertension. Cross-sectional and longitudinal analyses were conducted using normotensive subjects who were selected among 1399 subjects in the Tanno-Sobetsu cohort. In the cross-sectional analysis (n=740), blood pressure (BP) level was correlated with HOMA-IR and with ISI-M, but correlation coefficients indicate a tighter correlation with ISI-M. Multiple linear regression analysis adjusted by age, sex, body mass index (BMI) and serum triglyceride level (TG) showed contribution of ISI-M and fasting plasma glucose, but not of HOMA-IR. In the longitudinal analysis (n=607), 241 subjects (39.7%) developed hypertension during a 10-year follow-up period, and multiple logistic regression indicated that age, TG, systolic BP and ISI-M, but not HOMA-IR, were associated with development of hypertension. In subjects <60 years old, odds ratio of new-onset hypertension was higher in the low ISI-M group (ISI-M, less than the median) than in the high ISI-M group for any tertile of BMI. In conclusion, ISI-M is a better predictor of hypertension than is HOMA-IR. Non-hepatic IR may be a determinant, which is independent of TG, BP level and BMI, of the development of hypertension.
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