ArticlePharmacogenetics and genomics2011
Genetic variation in the presynaptic norepinephrine transporter is associated with blood pressure responses to exercise in healthy humans.
Article in Pharmacogenetics and genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- No major role of norepinephrine transporter gene variations in the cardiostimulant effects of MDMA.European journal of clinical pharmacology · 2018Trial
- Ketamine influences the locus coeruleus norepinephrine network, with a dependency on norepinephrine transporter genotype - a placebo controlled fMRI study.NeuroImage. Clinical · 2018Trial
- Factors Influencing the Cardiovascular Response to Subanesthetic Ketamine: A Randomized, Placebo-Controlled Trial.The international journal of neuropsychopharmacology · 2017Trial
- xNNPCD identifies regulators of programmed cell death by integrating perturbation transcriptomes with cancer dependency profiles.bioRxiv : the preprint server for biology · 2026Article
- Article
- Differentiation of rodent behavioral phenotypes and methylphenidate action in sustained and flexible attention tasks.Brain research · 2016Article
- Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise.Physiological genomics · 2015Article
- Norepinephrine transporter heterozygous knockout mice exhibit altered transport and behavior.Genes, brain, and behavior · 2013Article
- Effect of the rs168924 single-nucleotide polymorphism in the SLC6A2 catecholamine transporter gene on blood pressure in Caucasians.Journal of clinical hypertension (Greenwich, Conn.) · 2012Article
- Catecholamine pathway gene variation is associated with norepinephrine and epinephrine concentrations at rest and after exercise.Pharmacogenetics and genomics · 2012Article
- Vesicular and plasma membrane transporters for neurotransmitters.Cold Spring Harbor perspectives in biology · 2012Review
- SLC6 transporters: structure, function, regulation, disease association and therapeutics.Molecular aspects of medicineReview
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe presynaptic norepinephrine transporter (NET) mediates synaptic clearance and recycling of norepinephrine. NET-deficient transgenic mice have elevated blood pressure (BP), heart rate, and catecholamine concentrations. However, the in-vivo effects of common NET variants on cardiovascular regulation at rest and during exercise are unknown.
methodsWe studied cardiovascular responses and plasma catecholamine concentrations at rest and during bicycle exercise at increasing workloads (25, 50, and 75 W) in 145 healthy participants. We used multiple linear regressions to analyze the effect of common, purportedly functional polymorphisms in NET (rs2242446 and rs28386840) on cardiovascular measures.
results44 and 58.9% of participants carried at least one variant allele for NET T-182C and A-3081T, respectively. Systolic BP during exercise and systolic BP-area under the curve were higher in carriers of variant NET alleles (P=0.003 and 0.009 for T-182C and A-3081T, respectively) and NET haplotype -182C/-3081T compared with -182T/-3081A (all P<0.01). Diastolic BP during exercise was also higher at lower, but not at higher exercise stages in carriers of NET -182C (P<0.01) and -3081T variants (P<0.05). NET genotypes were not associated with catecholamine concentrations or heart rate.
conclusionCommon genetic NET variants (-182C and -3081T) are associated with greater BP response to exercise in humans.
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