Evidence map›Paper›PMID 21411975›Full record

ReviewJournal of innate immunity2011

Natural killer cell responses to viral infection.

Joshua D Brandstadter, Yiping Yang

Abstract readReview
In one paragraph

Review in Journal of innate immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Innate Immune and Inflammatory Responses to Dengue Virus Infection.Current topics in microbiology and immunology · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Off-the-shelf allogeneic natural killer cells for the treatment of COVID-19.Molecular therapy. Methods & clinical development · 2024
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joshua D BrandstadterMolecular Cancer Biology Program, Duke University Medical Center, Durham, NC 27710, USA.
Yiping Yang

Funding

THERAPEUTIC APPROACHES TO OVARIAN/BREAST CANCER--HIGH DOSE CHEMOTHERAPY AND ABMSP01CA047741 · NCI · DUKE UNIVERSITY · PI HASSELBLAD, VICTOR · 1990 to 2013
$19.5M
Novel Strategies for Cancer Immunotherapy in Stem Cell TransplantR01CA136934 · NCI · OHIO STATE UNIVERSITY · PI YANG, YIPING · 2009 to 2018
$3.4M
Mechanisms for NK Cell Activation in Vaccinia Virus ControlU01AI083000 · NIAID · DUKE UNIVERSITY · PI YANG, YIPING · 2009 to 2013
$2.8M
The Role of Toll-Like Receptors in Cancer ImmunotherapyR01CA111807 · NCI · DUKE UNIVERSITY · PI YANG, YIPING · 2005 to 2009
$1.7M
NCI NIH HHS CA047741NCI NIH HHS CA111807NCI NIH HHS CA136934NCI NIH HHS P01 CA047741NCI NIH HHS R01 CA111807NCI NIH HHS R01 CA136934NIAID NIH HHS AI083000NIAID NIH HHS U01 AI083000
6 · The paper itself

Abstract

Natural killer (NK) cells, as part of the innate immune system, play a key role in host defense against viral infections. Recent advances have indicated that NK cell activation and function are regulated by the interplay between inhibitory and activating signals. Thus, a better understanding of mechanisms responsible for NK cell activation and function in the control of viral infections will help develop NK cell-based therapies. In this review, we will first discuss how NK cells are activated in response to viral infections. We will then focus on the recruitment of activated NK cells to the site of infection as well as on NK cell effector mechanisms against virally infected cells.

Indexed as

ImmunotherapyAnimalsCell MovementCytotoxicity, ImmunologicHumansImmunity, InnateKiller Cells, NaturalLymphocyte ActivationVirus Diseases

Identifiers

PMID21411975
PMCPMC3128146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.