ReviewJournal of innate immunity2011
Killer immunoglobulin-like receptor transcriptional regulation: a fascinating dance of multiple promoters.
Review in Journal of innate immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Trial
- Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations.Molecular therapy oncolytics · 2023Article
- Novel Approach to Cell Surface Discrimination Between KIR2DL1 Subtypes and KIR2DS1 Identifies Hierarchies in NK Repertoire, Education, and Tolerance.Frontiers in immunology · 2019Article
- Hepatitis C Virus and Human Cytomegalovirus-Natural Killer Cell Subsets in Persistent Viral Infections.Frontiers in immunology · 2017Review
- Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells.PLoS biology · 2016Article
- KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles.Scientific reports · 2016Article
- Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome.Oncotarget · 2015Article
- Tissue-Specific Education of Decidual NK Cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The distal upstream promoter in Ly49 genes, Pro1, is active in mature NK cells and T cells, does not require TATA boxes, and displays enhancer activity.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Cancer Immunotherapy.Frontiers in immunology · 2015Review
- Characterization of a weakly expressed KIR2DL1 variant reveals a novel upstream promoter that controls KIR expression.Genes and immunity · 2014Article
- Identification of a KIR antisense lncRNA expressed by progenitor cells.Genes and immunity · 2013Article
- Allelic variation in KIR2DL3 generates a KIR2DL2-like receptor with increased binding to its HLA-C ligand.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Article
- IL-2/IL-15 activate the human clonally restricted KIR3DL1 reverse promoter.Genes and immunity · 2013Article
- Natural killer cell inhibitory receptor expression in humans and mice: a closer look.Frontiers in immunology · 2013Article
- CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells.Blood · 2012Article
- KIR2DL5: An Orphan Inhibitory Receptor Displaying Complex Patterns of Polymorphism and Expression.Frontiers in immunology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Killer immunoglobulin-like receptors (KIRs) recognize class I major histocompatibility complex molecules and participate in the calibration of activation thresholds during human natural killer (NK) cell development. The stochastic expression pattern of the KIR repertoire follows the product rule, meaning that the probability of the coexpression of two or more different KIRs equals the product of the individual expression frequencies for those KIRs. The expression frequencies of individual KIRs are independent of major histocompatibility complex class I and are instead established and maintained by a dynamic, yet ill-defined, transcriptional program. Here, we review recent advances in our understanding of the architecture of the regulatory regions within KIR genes and discuss a potential role for non-coding RNA in KIR transcriptional regulation during NK cell development. Understanding the molecular mechanisms that underlie KIR expression may help guide us in the design of novel, rational strategies for the use of NK cells in transplantation and immunotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.