ReviewILAR journal2011
The development of small primate models for aging research.
Review in ILAR journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 91 citations in OpenAlex.
- Article
- Characterization of sinoatrial automaticity in Microcebus murinus to study the effect of aging on cardiac activity and the correlation with longevity.Scientific reports · 2023Article
- Detection and characterization of resting state functional networks in squirrel monkey brain.Cerebral cortex communications · 2023Article
- Development and validation of an LC-MS/MS based quantitative assay for marmoset insulin in serum.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2022Article
- Analysis of gut microbiome profiles in common marmosets (Callithrix jacchus) in health and intestinal disease.Scientific reports · 2022Article
- Sex differences in cognitive aging: a 4-year longitudinal study in marmosets.Neurobiology of aging · 2022Article
- The marmoset as an important primate model for longitudinal studies of neurocognitive aging.American journal of primatology · 2021Article
- New Perspectives on Avian Models for Studies of Basic Aging Processes.Biomedicines · 2021Review
- Fibrous Osteodystrophy, Chronic Renal Disease, and Uterine Adenocarcinoma in Aged Gray Mouse Lemurs (Comparative medicine · 2021Article
- Age Associated Microbiome and Microbial Metabolites Modulation and Its Association With Systemic Inflammation in a Rhesus Macaque Model.Frontiers in immunology · 2021Article
- The Gastrointestinal Microbiota of the Common Marmoset (Callithrix jacchus).ILAR journal · 2020Review
- Neurobiological substrates of animal personality and cognition in a nonhuman primate (Microcebus murinus).Brain and behavior · 2020Article
- Evidence of the Role of Omega-3 Polyunsaturated Fatty Acids in Brain Glucose Metabolism.Nutrients · 2020Review
- Metabolism of sleep and aging: Bridging the gap using metabolomics.Nutrition and healthy aging · 2019Review
- Encephalopathy induced by Alzheimer brain inoculation in a non-human primate.Acta neuropathologica communications · 2019Article
- MarmoDetector: A novel 3D automated system for the quantitative assessment of marmoset behavior.Journal of neuroscience methods · 2019Article
- One-year change in cognitive flexibility and fine motor function in middle-aged male and female marmosets (Callithrix jacchus).American journal of primatology · 2019Article
- The metabolome as a biomarker of mortality risk in the common marmoset.American journal of primatology · 2019Article
- Strengths and Weaknesses of the Gray Mouse Lemur (Frontiers in pharmacology · 2019Review
- Aging research using the common marmoset: Focus on aging interventions.Nutrition and healthy aging · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nonhuman primate (NHP) aging research has traditionally relied mainly on the rhesus macaque. But the long lifespan, low reproductive rate, and relatively large body size of macaques and related Old World monkeys make them less than ideal models for aging research. Manifold advantages would attend the use of smaller, more rapidly developing, shorter-lived NHP species in aging studies, not the least of which are lower cost and the ability to do shorter research projects. Arbitrarily defining "small" primates as those weighing less than 500 g, we assess small, relatively short-lived species among the prosimians and callitrichids for suitability as models for human aging research. Using the criteria of availability, knowledge about (and ease of) maintenance, the possibility of genetic manipulation (a hallmark of 21st century biology), and similarities to humans in the physiology of age-related changes, we suggest three species--two prosimians (Microcebus murinus and Galago senegalensis) and one New World monkey (Callithrix jacchus)--that deserve scrutiny for development as major NHP models for aging studies. We discuss one other New World monkey group, Cebus spp., that might also be an effective NHP model of aging as these species are longer-lived for their body size than any primate except humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.