ArticleMolecular biology of the cell2011
Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Histochemical study of cingulin and CD34 in the skin of a stray Dog.Open veterinary journal · 2026Article
- Article
- Zonula Occludens Proteins Signaling in Inflammation and Tumorigenesis.International journal of biological sciences · 2023Review
- 27-Hydroxycholesterol induces expression of zonula occludens-1 in monocytic cells via multiple kinases pathways.Scientific reports · 2022Article
- Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis.Mucosal immunology · 2022Article
- Claudins and Gastric Cancer: An Overview.Cancers · 2022Review
- Tight Junction ZO Proteins Maintain Tissue Fluidity, Ensuring Efficient Collective Cell Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Transcriptional and Epigenetic Bioinformatic Analysis of Claudin-9 Regulation in Gastric Cancer.Journal of oncology · 2021Article
- miR-632 Promotes Laryngeal Carcinoma Cell Proliferation, Migration, and Invasion Through Negative Regulation of GSK3β.Oncology research · 2020Article
- Tight Junctions in Cell Proliferation.International journal of molecular sciences · 2019Review
- Cell-Cell Junctions Organize Structural and Signaling Networks.Cold Spring Harbor perspectives in biology · 2018Review
- Tight junction CLDN2 gene is a direct target of the vitamin D receptor.Scientific reports · 2015Article
- ZO proteins redundantly regulate the transcription factor DbpA/ZONAB.The Journal of biological chemistry · 2014Article
- Epithelial junctions and Rho family GTPases: the zonular signalosome.Small GTPases · 2014Review
- Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion.Cell cycle (Georgetown, Tex.) · 2014Article
- Delineation of the key aspects in the regulation of epithelial monolayer formation.Molecular and cellular biology · 2013Article
- Salmonella infection upregulates the leaky protein claudin-2 in intestinal epithelial cells.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Coordinated regulation of cell proliferation is vital for epithelial tissue homeostasis, and uncontrolled proliferation is a hallmark of carcinogenesis. A growing body of evidence indicates that epithelial tight junctions (TJs) play a role in these processes, although the mechanisms involved are poorly understood. In this study, we identify and characterize a novel plasma membrane pool of cyclin D1 with cell-cycle regulatory functions. We have determined that the zonula occludens (ZO) family of TJ plaque proteins sequesters cyclin D1 at TJs during mitosis, through an evolutionarily conserved class II PSD-95, Dlg, and ZO-1 (PDZ)-binding motif within cyclin D1. Disruption of the cyclin D1/ZO complex through mutagenesis or siRNA-mediated suppression of ZO-3 resulted in increased cyclin D1 proteolysis and G(0)/G(1) cell-cycle retention. This study highlights an important new role for ZO family TJ proteins in regulating epithelial cell proliferation through stabilization of cyclin D1 during mitosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.