ArticleMolecular biology of the cell2011
Multiple mechanisms actively target the SUN protein UNC-84 to the inner nuclear membrane.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- A network of nuclear envelope proteins and cytoskeletal force generators mediates movements of and within nuclei throughoutExperimental biology and medicine (Maywood, N.J.) · 2019Review
- Patrolling the nucleus: inner nuclear membrane-associated degradation.Current genetics · 2019Review
- Distribution of Proteins at the Inner Nuclear Membrane Is Regulated by the Asi1 E3 Ligase inGenetics · 2019Article
- LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining.The Journal of cell biology · 2016Article
- Nuclear Envelope Retention of LINC Complexes Is Promoted by SUN-1 Oligomerization in the Caenorhabditis elegans Germ Line.Genetics · 2016Article
- Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins.Molecular biology of the cell · 2015Article
- Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2.Structure (London, England : 1993) · 2015Article
- Diffusion and retention are major determinants of protein targeting to the inner nuclear membrane.The Journal of cell biology · 2015Article
- SUN proteins and nuclear envelope spacing.Nucleus (Austin, Tex.) · 2015Review
- The Caenorhabditis elegans SUN protein UNC-84 interacts with lamin to transfer forces from the cytoplasm to the nucleoskeleton during nuclear migration.Molecular biology of the cell · 2014Article
- The SUN protein UNC-84 is required only in force-bearing cells to maintain nuclear envelope architecture.The Journal of cell biology · 2014Article
- Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.Circulation research · 2014Review
- Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope.PloS one · 2014Article
- Structural insights into LINC complexes.Current opinion in structural biology · 2013Review
- Mapping of sequences in Pseudorabies virus pUL34 that are required for formation and function of the nuclear egress complex.Journal of virology · 2013Article
- Spreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegans.PLoS genetics · 2013Article
- Connecting the nucleus to the cytoskeleton by SUN-KASH bridges across the nuclear envelope.Current opinion in cell biology · 2013Review
- Article
- Many mechanisms, one entrance: membrane protein translocation into the nucleus.Cellular and molecular life sciences : CMLS · 2012Review
- Trafficking to uncharted territory of the nuclear envelope.Current opinion in cell biology · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Approximately 100 proteins are targeted to the inner nuclear membrane (INM), where they regulate chromatin and nuclear dynamics. The mechanisms underlying trafficking to the INM are poorly understood. The Caenorhabditis elegans SUN protein UNC-84 is an excellent model to investigate such mechanisms. UNC-84 recruits KASH proteins to the outer nuclear membrane to bridge the nuclear envelope (NE), mediating nuclear positioning. UNC-84 has four targeting sequences: two classical nuclear localization signals, an INM sorting motif, and a signal conserved in mammalian Sun1, the SUN--nuclear envelope localization signal. Mutations in some signals disrupt the timing of UNC-84 nuclear envelope localization, showing that diffusion is not sufficient to move all UNC-84 to the NE. Thus targeting UNC-84 requires an initial step that actively transports UNC-84 from the peripheral endoplasmic reticulum to the NE. Only when all four signals are simultaneously disrupted does UNC-84 completely fail to localize and to function in nuclear migration, meaning that at least three signals function, in part, redundantly to ensure proper targeting of UNC-84. Multiple mechanisms might also be used to target other proteins to the INM, thereby ensuring their proper and timely localization for essential cellular and developmental functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.