Evidence map›Paper›PMID 21411615›Full record

Trial reportThe American journal of clinical nutrition2011

Effects of cranberry juice consumption on vascular function in patients with coronary artery disease.

Mustali M Dohadwala, Monika Holbrook, Naomi M Hamburg, Sherene M Shenouda, William B Chung, Megan Titas, Matthew A Kluge, Na Wang, Joseph Palmisano, Paul E Milbury and 2 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00553904 (Long-Term Effects of Cranberry Juice on Endothelial Function in Patients With Coronary Artery Disease), which is not on this map. Cited by 90 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 13 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00553904 nacompletednot on this map

Long-Term Effects of Cranberry Juice on Endothelial Function in Patients With Coronary Artery Disease

TypeinterventionalSponsorBoston UniversityRan2008 to 2009Enrolled40ConditionsCoronary Artery DiseaseArmsCranberry juice
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 13 syntheses or guidelines pooled it, 267 citations in OpenAlex.

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  20. Potential of anthocyanin as an anti-inflammatory agent: a human clinical trial on type 2 diabetic, diabetic at-risk and healthy adults.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Mustali M DohadwalaEvans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
Monika Holbrook
Naomi M Hamburg
Sherene M Shenouda
William B Chung
Megan Titas
Matthew A Kluge
Na Wang
Joseph Palmisano
Paul E Milbury
Jeffrey B Blumberg
Joseph A Vita
Boston University · US

Funding

Redox regulation in Endothelial Progenitor CellsP01HL081587 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALSH, KENNETH · 2005 to 2015
$21.5M
YOGA INDUCED CHANGES IN BRAIN GABA LEVELSM01RR000533 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HOLICK, MICHAEL F. · 1985 to 2008
$19.4M
Multidisciplinary Training in Cardiovascular ResearchT32HL007224 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAMBURG, NAOMI MIRIAM, WAINFORD, RICHARD DAVID · 1985 to 2020
$12.3M
Vascular Consequences of Insulin Resistance and ObesityP50HL083801 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI VITA, JOSEPH A. · 2006 to 2010
$11.2M
Clinical Utility of Endothelial Function in PADR01HL075795 · NHLBI · BOSTON MEDICAL CENTER · PI VITA, JOSEPH A. · 2003 to 2007
$4.9M
Boston University Medical Center Leadership Program in Vascular MedicineK12HL083781 · NHLBI · BOSTON MEDICAL CENTER · PI EBERHARDT, ROBERT THOMAS · 2007 to 2013
$3.4M
Endothelial Insulin Resistance, Inflammation and Vascular Function in DiabetesR01HL102299 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAMBURG, NAOMI MIRIAM · 2010 to 2014
$2.0M
Determinants of Shear Stress-Mediated Arterial RemodelingR01HL083269 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI VITA, JOSEPH A. · 2006 to 2009
$1.9M
NCRR NIH HHS M01RR00533NHLBI NIH HHS HL081587NHLBI NIH HHS HL083269NHLBI NIH HHS HL083801NHLBI NIH HHS HL102299NHLBI NIH HHS HL75795NHLBI NIH HHS K12HL083781NHLBI NIH HHS P01 HL081587NHLBI NIH HHS P50 HL083801NHLBI NIH HHS R01 HL075795NHLBI NIH HHS R01 HL083269NHLBI NIH HHS T32 HL 07224
6 · The paper itself

Abstract

backgroundCranberry juice contains polyphenolic compounds that could improve endothelial function and reduce cardiovascular disease risk.

objectiveThe objective was to examine the effects of cranberry juice on vascular function in subjects with coronary artery disease.

designWe completed an acute pilot study with no placebo (n = 15) and a chronic placebo-controlled crossover study (n = 44) that examined the effects of cranberry juice on vascular function in subjects with coronary artery disease.

resultsIn the chronic crossover study, subjects with coronary heart disease consumed a research preparation of double-strength cranberry juice (54% juice, 835 mg total polyphenols, and 94 mg anthocyanins) or a matched placebo beverage (480 mL/d) for 4 wk each with a 2-wk rest period between beverages. Beverage order was randomly assigned, and participants refrained from consuming other flavonoid-containing beverages during the study. Vascular function was measured before and after each beverage, with follow-up testing ≥12 h after consumption of the last beverage. Mean (±SD) carotid-femoral pulse wave velocity, a measure of central aortic stiffness, decreased after cranberry juice (8.3 ± 2.3 to 7.8 ± 2.2 m/s) in contrast with an increase after placebo (8.0 ± 2.0 to 8.4 ± 2.8 m/s) (P = 0.003). Brachial artery flow-mediated dilation, digital pulse amplitude tonometry, blood pressure, and carotid-radial pulse wave velocity did not change. In the uncontrolled pilot study, we observed improved brachial artery flow-mediated dilation (7.7 ± 2.9% to 8.7 ± 3.1%, P = 0.01) and digital pulse amplitude tonometry ratio (0.10 ± 0.12 to 0.23 ± 0.16, P = 0.001) 4 h after consumption of a single 480-mL portion of cranberry juice.

conclusionsChronic cranberry juice consumption reduced carotid femoral pulse wave velocity-a clinically relevant measure of arterial stiffness. The uncontrolled pilot study suggested an acute benefit; however, no chronic effect on measures of endothelial vasodilator function was found. This trial was registered at clinicaltrials.gov as NCT00553904.

Indexed as

BeveragesFruitHemodynamicsVaccinium macrocarponAgedAnthocyaninsBlood PressureCardiovascular SystemCoronary Artery DiseaseCross-Over StudiesDouble-Blind MethodElasticityFemaleFlavonoidsHumansMaleAnthocyaninsFlavonoidsPhenolsPolyphenols

Identifiers

PMID21411615
PMCPMC3076649
OpenAlexW2153760319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.