ArticleClinical and vaccine immunology : CVI2011
Reference values of lymphocyte subsets in healthy, HIV-negative children in Cameroon.
Article in Clinical and vaccine immunology : CVI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Novel polyomaviruses of nonhuman primates: genetic and serological predictors for the existence of multiple unknown polyomaviruses within the human population.PLoS pathogens · 2013Trial
- Long-Term Clinical, Immunologic, and Viral Reservoir Outcomes in Children Treated With VRC01LS and 10-1074 Monoclonal Antibodies in the Tatelo Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Evaluating Pediatric Reference Ranges for Extended Immunophenotyping from a Finnish Cohort against Published References.Journal of clinical immunology · 2025Review
- Liver injury and prolonged hospitalization as indicators of severity in patients with adenovirus infections.BMC infectious diseases · 2024Article
- Normative data for paediatric lymphocyte subsets: A pilot study from western India.The Indian journal of medical research · 2023Article
- Establishing Reference Values for Peripheral Blood Lymphocyte Subsets of Healthy Children in China Using a Single Platform.Journal of immunology research · 2022Article
- Region-specific laboratory reference intervals are important: A systematic review of the data from Africa.PLOS global public health · 2022Article
- Normalization of B Cell Subsets but Not T Follicular Helper Phenotypes in Infants With Very Early Antiretroviral Treatment.Frontiers in pediatrics · 2021Article
- A Critical Review on the Standardization and Quality Assessment of Nonfunctional Laboratory Tests Frequently Used to Identify Inborn Errors of Immunity.Frontiers in immunology · 2021Review
- Comparison of Lymphocyte Subset Populations in Children From South Africa, US and Europe.Frontiers in pediatrics · 2020Article
- BetaHPV E6 and E7 colocalize with NuMa in dividing keratinocytes.Virus genes · 2019Article
- Rates of HBV, HCV, HDV and HIV type 1 among pregnant women and HIV type 1 drug resistance-associated mutations in breastfeeding women on antiretroviral therapy.BMC pregnancy and childbirth · 2018Article
- Poorly cytotoxic terminally differentiated CD56Blood advances · 2018Article
- Article
- Nutritional and Immunological Correlates of Memory and Neurocognitive Development Among HIV-Infected Children Living in Kayunga, Uganda.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Changes in cellular immune activation and memory T-cell subsets in HIV-infected Zambian children receiving HAART.Journal of acquired immune deficiency syndromes (1999) · 2014Observational
- Lymphocyte subsets in human immunodeficiency virus-unexposed Brazilian individuals from birth to adulthood.Memorias do Instituto Oswaldo Cruz · 2014Observational
- Control lymphocyte subsets: can one country's values serve for another's?The Journal of allergy and clinical immunology · 2014Article
- Single-platform, volumetric, CD45-assisted pan-leucogating flow cytometry for CD4 T lymphocytes monitoring of HIV infection according to the WHO recommendations for resource-constrained settings.BMC research notes · 2013Article
- Validation of a single-platform, volumetric, CD45-assisted PanLeucogating Auto40 flow cytometer to determine the absolute number and percentages of CD4 T cells in resource-constrained settings using Cameroonian patients' samples.Clinical and vaccine immunology : CVI · 2012Article
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Authors and funding
12 authors.
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Abstract
Lymphocyte subset reference values used to monitor infectious diseases, including HIV/AIDS, tuberculosis, malaria, or other immunological disorders in healthy children in Cameroon, are lacking. Values for Caucasian cohorts are already being utilized for clinical decisions but could be inappropriate for African populations. We report here the immunological profile for children aged from birth through 6 years in Cameroon and also compare our values to data from other African and Caucasian populations. In a cohort of 352 healthy children, aged 0 to 6 years, the relative and absolute numbers of T-cell subsets, B cells, and NK lymphocytes were determined from peripheral blood collected in EDTA tubes. Samples were stained with BD Multitest reagents in Trucount tubes and analyzed by using CellQuest-Pro and FlowJo software. We evaluated about 23 different lymphocyte subsets in which the absolute number and percentage values differed significantly (P < 0.05) with age and peaked between 6 and 12 months. B-cell values were higher compared to reported values from developed countries. Differences in activated and differentiated T cells were observed in subjects between 1 and 6 years of age. The absolute CD8(+) T-cell count and the CD4(+)/CD8(+) ratio seem to depend on gender. Normal lymphocyte subsets values among children from Cameroon differ from reported values in Caucasian and some African populations. The differences observed could be due to genetic and environmental factors coupled with the methodology used. These values could be used as initial national reference guidelines as more data are assembled.
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