ArticleJournal of virology2011
Natural killer cells recognize friend retrovirus-infected erythroid progenitor cells through NKG2D-RAE-1 interactions In Vivo.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Dietary lipid overload creates a suppressive environment that impedes the antiviral functions of NK cells.iScience · 2025Article
- Article
- Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity.FEMS microbiology reviews · 2019Review
- The Cytotoxic Activity of Natural Killer Cells Is Suppressed by IL-10Frontiers in immunology · 2018Article
- Dose of Retroviral Infection Determines Induction of Antiviral NK Cell Responses.Journal of virology · 2017Article
- Natural killer T cells contribute to the control of acute retroviral infection.Retrovirology · 2017Article
- Insufficient natural killer cell responses against retroviruses: how to improve NK cell killing of retrovirus-infected cells.Retrovirology · 2016Review
- A novel TLR7 agonist reverses NK cell anergy and cures RMA-S lymphoma-bearing mice.Oncoimmunology · 2016Article
- Tetherin promotes the innate and adaptive cell-mediated immune response against retrovirus infection in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Infection of adult thymus with murine retrovirus induces virus-specific central tolerance that prevents functional memory CD8+ T cell differentiation.PLoS pathogens · 2014Article
- Elimination of friend retrovirus in the absence of CD8+ T cells.Journal of virology · 2014Article
- Influenza infection results in local expansion of memory CD8(+) T cells with antigen non-specific phenotype and function.Clinical and experimental immunology · 2014Article
- Differential requirements of cellular and humoral immune responses for Fv2-associated resistance to erythroleukemia and for regulation of retrovirus-induced myeloid leukemia development.Journal of virology · 2013Article
- Distinct roles of NK cells in viral immunity during different phases of acute Friend retrovirus infection.Retrovirology · 2013Article
- Two genetic determinants acquired late in Mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency.PLoS pathogens · 2012Article
- Interferon-alpha subtype 11 activates NK cells and enables control of retroviral infection.PLoS pathogens · 2012Article
- Toll-like receptor 7 controls the anti-retroviral germinal center response.PLoS pathogens · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural killer (NK) cells function as early effector cells in the innate immune defense against viral infections and also participate in the regulation of normal and malignant hematopoiesis. NK cell activities have been associated with early clearance of viremia in experimental simian immunodeficiency virus and clinical human immunodeficiency virus type 1 (HIV-1) infections. We have previously shown that NK cells function as major cytotoxic effector cells in vaccine-induced immune protection against Friend virus (FV)-induced leukemia, and NK cell depletion totally abrogates the above protective immunity. However, how NK cells recognize retrovirus-infected cells remains largely unclear. The present study demonstrates a correlation between the expression of the products of retinoic acid early transcript-1 (RAE-1) genes in target cells and their susceptibility to killing by NK cells isolated from FV-infected animals. This killing was abrogated by antibodies blocking the NKG2D receptor in vitro. Further, the expression of RAE-1 proteins on erythroblast surfaces increased early after FV inoculation, and administration of an RAE-1-blocking antibody resulted in increased spleen infectious centers and exaggerated pathology, indicating that FV-infected erythroid cells are recognized by NK cells mainly through the NKG2D-RAE-1 interactions in vivo. Enhanced retroviral replication due to host gene-targeting resulted in markedly increased RAE-1 expression in the absence of massive erythroid cell proliferation, indicating a direct role of retroviral replication in RAE-1 upregulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.