Evidence map›Paper›PMID 21411369›Full record

ReviewTrends in molecular medicine2011

Non-coding RNA networks underlying cognitive disorders across the lifespan.

Irfan A Qureshi, Mark F Mehler

Abstract readReview
In one paragraph

Review in Trends in molecular medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. The Astroglia Syncytial Theory of Consciousness.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Noncoding RNAs in neurodegeneration.Nature reviews. Neuroscience · 2017
    Review
  19. Article
  20. Long noncoding RNAs in diseases of aging.Biochimica et biophysica acta · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Irfan A QureshiRosyln and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA. irfan@jhu.edu
Mark F Mehler

Funding

Support for MRRC - Biometry CoreP30HD001799 · NICHD · YESHIVA UNIVERSITY · PI FABER, DONALD S · 1985 to 2005
$6.5M
Mechanisms Regulating Astroglial Lineage DevelopmentR01MH066290 · NIMH · YESHIVA UNIVERSITY · PI MEHLER, MARK F · 2002 to 2006
$1.8M
Neurodegenerative Diseases: A New Class of Primary Developmental Disorders?R01NS071571 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MEHLER, MARK F · 2010 to 2013
$1.3M
REGULATION OF POSTNATAL CORTICAL MULTIPOTENT PROGENITORSR01NS038902 · NINDS · YESHIVA UNIVERSITY · PI MEHLER, MARK F · 1999 to 2002
$886k
NICHD NIH HHS P30 HD001799NIMH NIH HHS MH66290NIMH NIH HHS R01 MH066290NINDS NIH HHS NS071571NINDS NIH HHS NS38902NINDS NIH HHS R01 NS038902NINDS NIH HHS R01 NS071571
6 · The paper itself

Abstract

Non-coding RNAs (ncRNAs) and their associated regulatory networks are increasingly being implicated in mediating a complex repertoire of neurobiological functions. Cognitive and behavioral processes are proving to be no exception. In this review, we discuss the emergence of many novel, diverse and rapidly expanding classes and subclasses of short and long ncRNAs. We briefly review the life cycles and molecular functions of these ncRNAs. We also examine how ncRNA circuitry mediates brain development, plasticity, stress responses and aging, and highlight its potential roles in the pathophysiology of cognitive disorders, including neural developmental and age-associated neurodegenerative diseases, as well as those that manifest throughout the lifespan.

Indexed as

RNA, UntranslatedAgingBrainCognition DisordersGene Expression RegulationHumansMicroRNAsModels, BiologicalNervous System DiseasesMicroRNAsRNA, Untranslated

Identifiers

PMID21411369
PMCPMC3115489

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.