Evidence map›Paper›PMID 21411243›Full record

Trial reportDrug and alcohol dependence2011

Cigarette and cannabis use trajectories among adolescents in treatment for attention-deficit/hyperactivity disorder and substance use disorders.

Kevin M Gray, Paula D Riggs, Sung-Joon Min, Susan K Mikulich-Gilbertson, Dipankar Bandyopadhyay, Theresa Winhusen

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Drug and alcohol dependence, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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  12. Saliva DNA Methylation Detects Nascent Smoking in Adolescents.Journal of child and adolescent psychopharmacology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kevin M GrayDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, MSC861, Charleston, SC 29425, USA. graykm@musc.edu
Paula D Riggs
Sung-Joon Min
Susan K Mikulich-Gilbertson
Dipankar Bandyopadhyay
Theresa Winhusen
University of Colorado Anschutz Medical Campus · USMedical University of South Carolina · USUniversity of Cincinnati Medical Center · US

Funding

Clinical Trials Network, Ohio Valley Node U10DA013732U10DA013732 · NIDA · UNIVERSITY OF CINCINNATI · PI WINHUSEN, T JOHN · 2000 to 2015
$45.0M
Southern Consortium Node of the Clinical Trials NetworkU10DA013727 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2000 to 2015
$34.4M
ROCKY MOUNTAIN REGIONAL CLINICAL TRIALS NODEU10DA013716 · NIDA · UNIVERSITY OF COLORADO DENVER/HSC DENVER · PI RIGGS, PAULA DEGRAFFENREID · 2000 to 2005
$12.7M
A Controlled Trial of N-Acetylcysteine (NAC) in Cannabis Dependent AdolescentsR01DA026777 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GRAY, KEVIN M · 2009 to 2010
$722k
NIDA NIH HHS R01 DA026777NIDA NIH HHS R01DA026777NIDA NIH HHS U10 DA013716NIDA NIH HHS U10 DA013727NIDA NIH HHS U10 DA013732
6 · The paper itself

Abstract

backgroundCigarette smoking is common in adolescents with attention-deficit/hyperactivity disorder (ADHD) and substance use disorders (SUD). However, little is known about the relationship between cigarette and cannabis use trajectories in the context of treatment for both ADHD and SUD. To address this research gap, we report collateral analyses from a 16-week randomized, controlled trial (n=303) of osmotic-release methylphenidate (OROS-MPH) in adolescents with ADHD concurrently receiving cognitive behavioral therapy (CBT) targeting non-nicotine SUD.

methodsParticipants completed cigarette and cannabis use self-report at baseline and throughout treatment. Analyses were performed to explore the relationships between cigarette smoking, cannabis use, and other factors, such as medication treatment assignment (OROS-MPH versus placebo).

resultsBaseline (pre-treatment) cigarette smoking was positively correlated with cannabis use. Negligible decline in cigarette smoking during treatment for non-nicotine SUD was observed in both medication groups. Regular cigarette and cannabis users at baseline who reduced their cannabis use by >50% also reduced cigarette smoking (from 10.8±1.1 to 6.2±1.1 cigarettes per day).

conclusionsFindings highlight the challenging nature of concurrent cannabis and cigarette use in adolescents with ADHD, but demonstrate that changes in use of these substances during treatment may occur in parallel.

Indexed as

Administration, OralAdolescentAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsCognitive Behavioral TherapyComorbidityDelayed-Action PreparationsDisease ProgressionFemaleHumansMaleMarijuana SmokingMethylphenidatePlacebosPsychiatric Status Rating ScalesSmokingCentral Nervous System StimulantsDelayed-Action PreparationsMethylphenidatePlacebos

Identifiers

PMID21411243
PMCPMC3128687
OpenAlexW2010891088

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.