ArticleLipids in health and disease2011
Metabolic syndrome in South Asian immigrants: more than low HDL requiring aggressive management.
Article in Lipids in health and disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Systematic Review of the Effect of Lifestyle Interventions on the Components of the Metabolic Syndrome in South Asian Migrants.Journal of immigrant and minority health · 2018Pooled it
- Unraveling Metabolic Syndrome in Youth: The Obesity Epidemic's Hidden Complication.Children (Basel, Switzerland) · 2025Review
- Cardiovascular Disease in South Asian Immigrants: a Review of Dysfunctional HDL as a Potential Marker.Journal of racial and ethnic health disparities · 2023Review
- Metabolic Syndrome and Chronic Disease Risk in South Asian Immigrants: A Review of Prevalence, Factors, and Interventions.Healthcare (Basel, Switzerland) · 2023Review
- Lipids in South Asians: Epidemiology and Management.Current cardiovascular risk reports · 2019Article
- Polyunsaturated fatty acids, inflammation, and metabolic syndrome in South Asian Americans in Maryland.Food science & nutrition · 2018Article
- The Colombo Twin and Singleton Follow-up Study: a population based twin study of psychiatric disorders and metabolic syndrome in Sri Lanka.BMC public health · 2018Article
- Prevalence of Metabolic Syndrome in Treatment Naïve Rheumatoid Arthritis and Correlation With Disease Parameters.Archives of rheumatology · 2017Article
- Lipoprotein abnormalities in South Asians and its association with cardiovascular disease: Current state and future directions.World journal of cardiology · 2016Review
- The prevalence of metabolic syndrome among low-income South Asian Americans.Public health nutrition · 2016Article
- Supporting South Asian Taxi Drivers to Exercise through Pedometers (SSTEP) to decrease cardiovascular disease risk.Journal of urban health : bulletin of the New York Academy of Medicine · 2014Article
- Prevalence of metabolic syndrome in women with rheumatoid arthritis and effective factors.International journal of clinical and experimental medicine · 2014Article
- Metabolic syndrome in rheumatoid arthritis: case control study.BMC musculoskeletal disorders · 2013Article
- Metabolic syndrome among Sri Lankan adults: prevalence, patterns and correlates.Diabetology & metabolic syndrome · 2012Article
- Metabolic syndrome in South Asians.Indian journal of endocrinology and metabolism · 2012Article
- APOA1 gene polymorphisms in the South Asian immigrant population in the United States.Indian journal of human genetics · 2011Article
- Presence of coronary artery disease in diabetic and non diabetic South Asian immigrants.Indian heart journalArticle
- Coronary artery disease in Bangladesh: a review.Indian heart journalReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Aggressive clinical and public health interventions have resulted in significant reduction in coronary artery disease (CAD) worldwide. However, South Asian immigrants (SAIs) exhibit the higher prevalence of CAD and its risk factors as compared with other ethnic populations. The objective of the current study is to assess the prevalence of metabolic syndrome (MS), its association with high density Lipoprotein (HDL) function, Apo lipoprotein A-I (APOA1) gene polymorphisms, and sub-clinical CAD using common carotid intima-media thickness (CCA-IMT) as a surrogate marker. A community-based cross-sectional study was conducted on SAIs aged 35-65 years. Dysfunctional/pro-inflammatory (Dys-HDL) was determined using novel cell free assay and HDL inflammatory index. Six intronic APOA1 gene polymorphisms were analyzed by DNA sequencing. According to the International Diabetes Federation definition, MS prevalence was 29.7% in SAIs without CAD and 26% had HDL inflammatory index ≥ 1 suggesting pro-inflammatory Dys-HDL. Six novel APOA1 single nucleotide polymorphisms (SNPs) were analyzed with logistic regression, three SNPs (G2, G3, and G5) were found to be significantly associated with MS (p = 0.039, p = 0.038, p = 0.054). On multi-variate analysis, MS was significantly associated with BMI > 23 (P = 0.005), Apo-A-I levels (p = 0.01), and Lp [a] (p < 0.0001). SAIs are known to be at a disproportionately high risk for CAD that may be attributed to a high burden for MS. There is need to explore and understand non-traditional risk factors with special focus on Dys-HDL, knowing that SAIs have low HDL levels. Large prospective studies are needed to further strengthen current study results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.