ArticleBMC systems biology2011
Gene networks associated with conditional fear in mice identified using a systems genetics approach.
Article in BMC systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
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- Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
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- Complementation testing identifies genes mediating effects at quantitative trait loci underlying fear-related behavior.Cell genomics · 2024Article
- Resource: A Curated Database of Brain-Related Functional Gene Sets (Brain.GMT).bioRxiv : the preprint server for biology · 2024Article
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- Genetic pathways regulating the longitudinal acquisition of cocaine self-administration in a panel of inbred and recombinant inbred mice.Cell reports · 2023Article
- Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice.Cell reports · 2023Article
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- Genetic background determines behavioral responses during fear conditioning.Neurobiology of learning and memory · 2021Article
- Noise Exposure and Distortion Product Otoacoustic Emission Suprathreshold Amplitudes: A Genome-Wide Association Study.Audiology & neuro-otology · 2021Article
- Single-step genome-wide association study for social genetic effects and direct genetic effects on growth in Landrace pigs.Scientific reports · 2020Article
- The Genetics of Variation of the Wave 1 Amplitude of the Mouse Auditory Brainstem Response.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Annotation and cluster analysis of long noncoding RNA linked to male sex and estrogen in cancers.NPJ precision oncology · 2020Article
- Distinct Expression Pattern of Epigenetic Machinery Genes in Blood Leucocytes and Brain Cortex of Depressive Patients.Molecular neurobiology · 2019Article
- Evaluation of Sirtuin-3 probe quality and co-expressed genes using literature cohesion.BMC bioinformatics · 2019Article
- Assessment of weighted topological overlap (wTO) to improve fidelity of gene co-expression networks.BMC bioinformatics · 2019Article
- Genomewide Association Study Identifies Cxcl Family Members as Partial Mediators of LPS-Induced Periodontitis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundOur understanding of the genetic basis of learning and memory remains shrouded in mystery. To explore the genetic networks governing the biology of conditional fear, we used a systems genetics approach to analyze a hybrid mouse diversity panel (HMDP) with high mapping resolution.
resultsA total of 27 behavioral quantitative trait loci were mapped with a false discovery rate of 5%. By integrating fear phenotypes, transcript profiling data from hippocampus and striatum and also genotype information, two gene co-expression networks correlated with context-dependent immobility were identified. We prioritized the key markers and genes in these pathways using intramodular connectivity measures and structural equation modeling. Highly connected genes in the context fear modules included Psmd6, Ube2a and Usp33, suggesting an important role for ubiquitination in learning and memory. In addition, we surveyed the architecture of brain transcript regulation and demonstrated preservation of gene co-expression modules in hippocampus and striatum, while also highlighting important differences. Rps15a, Kif3a, Stard7, 6330503K22RIK, and Plvap were among the individual genes whose transcript abundance were strongly associated with fear phenotypes.
conclusionApplication of our multi-faceted mapping strategy permits an increasingly detailed characterization of the genetic networks underlying behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.