ArticleThe FEBS journal2011
Glycomics-based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay.
Article in The FEBS journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 1 citations in OpenAlex.
- Article
- Article
- Model-based inference of neutralizing antibody avidities against influenza virus.PLoS pathogens · 2022Article
- Glycan remodeled erythrocytes facilitate antigenic characterization of recent A/H3N2 influenza viruses.Nature communications · 2021Article
- N-Glycomics of Human Erythrocytes.International journal of molecular sciences · 2021Article
- N-glycosylation of infectious bronchitis virus M41 spike determines receptor specificity.The Journal of general virology · 2020Article
- Replication of Influenza D Viruses of Bovine and Swine Origin in Ovine Respiratory Explants and Their Attachment to the Respiratory Tract of Bovine, Sheep, Goat, Horse, and Swine.Frontiers in microbiology · 2020Article
- Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition.Journal of virology · 2019Article
- A Y161F Hemagglutinin Substitution Increases Thermostability and Improves Yields of 2009 H1N1 Influenza A Virus in Cells.Journal of virology · 2018Article
- New insights into influenza A specificity: an evolution of paradigms.Current opinion in structural biology · 2017Review
- Glycosylation changes in the globular head of H3N2 influenza hemagglutinin modulate receptor binding without affecting virus virulence.Scientific reports · 2016Article
- Effects of egg-adaptation on receptor-binding and antigenic properties of recent influenza A (H3N2) vaccine viruses.The Journal of general virology · 2016Article
- Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus.Trends in microbiology · 2014Review
- Influenza virus-glycan interactions.Current opinion in virology · 2014Review
- Role of receptor binding specificity in influenza A virus transmission and pathogenesis.The EMBO journal · 2014Review
- H5N1 receptor specificity as a factor in pandemic risk.Virus research · 2013Review
- Modular glycosphere assays for high-throughput functional characterization of influenza viruses.BMC biotechnology · 2013Article
- Article
- Binding of avian coronavirus spike proteins to host factors reflects virus tropism and pathogenicity.Journal of virology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Agglutination of red blood cells (RBCs), including chicken RBCs (cRBCs), has been used extensively to estimate viral titer, to screen glycan-receptor binding preference, and to assess the protective response of vaccines. Although this assay enjoys widespread use, some virus strains do not agglutinate RBCs. To address these underlying issues and to increase the usefulness of cRBCs as tools for studying viruses, such as influenza, we analyzed the cell surface N-glycans of cRBCs. On the basis of the results obtained from complementary analytical strategies, including MS, 1D and 2D-NMR spectroscopy, exoglycosidase digestions, and HPLC profiling, we report the major glycan structures present on cRBCs. By comparing the glycan structures of cBRCs with those of representative human upper respiratory cells, we offer a possible explanation for the fact that certain influenza strains do not agglutinate cRBCs, using specific human-adapted influenza hemagglutinins as examples. Finally, recent understanding of the role of various glycan structures in high affinity binding to influenza hemagglutinins provides context to our findings. These results illustrate that the field of glycomics can provide important information with respect to the experimental systems used to characterize, detect and study viruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.