ArticleMolecular microbiology2011
Mechanism of adhesion maintenance by methionine sulphoxide reductase in Streptococcus gordonii.
Article in Molecular microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Where metabolism and virulence meet-sulfoxide reductases as determinants of bacterial survival.Biochemical Society transactions · 2026Review
- Article
- Methionine Redox Homeostasis in Protein Quality Control.Frontiers in molecular biosciences · 2021Review
- Pyruvate secretion by oral streptococci modulates hydrogen peroxide dependent antagonism.The ISME journal · 2020Article
- Article
- An intramembrane sensory circuit monitors sortase A-mediated processing of streptococcal adhesins.Science signaling · 2019Article
- The Role of Methionine Sulfoxide Reductases in Oxidative Stress Tolerance and Virulence ofAntioxidants (Basel, Switzerland) · 2018Review
- The Streptococcus mutans irvA gene encodes a trans-acting riboregulatory mRNA.Molecular cell · 2015Article
- Extracellular matrix-associated proteins form an integral and dynamic system during Pseudomonas aeruginosa biofilm development.Frontiers in cellular and infection microbiology · 2015Article
- Article
- Comparison of genes required for H2O2 resistance in Streptococcus gordonii and Streptococcus sanguinis.Microbiology (Reading, England) · 2014Article
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Methionine sulphoxide reductase maintains adhesin function during oxidative stress. Using Streptococcus gordonii as a model, we now show the mechanistic basis of adhesin maintenance provided by MsrA. In biofilms, S. gordonii selectively expresses the msrA gene. When the wild-type strain was grown with exogenous hydrogen peroxide (H(2)O(2)), msrA-specific mRNA expression significantly increased, while acid production was unaffected. In the presence of H(2)O(2), a msrA-deletion mutant (ΔMsrA) showed a 6 h delay in lag phase growth, a 30% lower yield of H(2)O(2), significantly greater inhibition by H(2)O(2) on agar plates (reversed by complementation), 30% less adhesion to saliva-coated hydroxyapatite, 87% less biofilm formation and an altered electrophoretic pattern of SspAB protein adhesins. Using mass spectrometry, methionine residues in the Met-rich central region of SspB were shown to be oxidized by H(2)O(2) and reduced by MsrA. In intact wild-type cells, MsrA colocalized with a cell wall-staining dye, and MsrA was detected in both cell wall and cytosolic fractions. To maintain normal adhesion and biofilm function of S. gordonii in response to exogenous oxidants therefore msrA is upregulated, methionine oxidation of adhesins and perhaps other proteins is reversed, and adhesion and biofilm formation is maintained.
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