ArticleBritish journal of pharmacology2011
Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction.
Article in British journal of pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Trajectory of serum osmolality changes and 28-day mortality risk in patients with sepsis-associated delirium based on the MIMIC-IV database.Scientific reports · 2025Article
- Targeting PANoptosis: a promising therapeutic strategy for ALI/ARDS.Apoptosis : an international journal on programmed cell death · 2025Review
- The Role of the NO/cGMP Pathway and SKCa and IKCa Channels in the Vasodilatory Effect of Apigenin 7-Glucoside.Molecules (Basel, Switzerland) · 2025Article
- Vasodilator Effects of Quercetin 3-O-Malonylglucoside Are Mediated by the Activation of Endothelial Nitric Oxide Synthase and the Opening of Large-Conductance Calcium-Activated KMolecules (Basel, Switzerland) · 2025Article
- Analysis of the correlation between the group-based trajectory modeling of serum osmolality and prognosis in patients with sepsis-associated encephalopathy at 72 h after admission.BMC infectious diseases · 2025Article
- The U-shaped association between serum osmolality and 28-day mortality in patients with sepsis: a retrospective cohort study.Infection · 2024Article
- Doxycycline reduces liver and kidney injuries in a rat hemorrhagic shock model.Intensive care medicine experimental · 2024Article
- Association of serum potassium levels with mortality in critically ill patients with sepsis during hospitalization.PloS one · 2024Article
- A New Nomogram for Predicting 30-Day In-Hospital Mortality Rate of Acute Cholangitis Patients in the Intensive Care Unit.Emergency medicine international · 2023Article
- The role of nitric oxide in sepsis-associated kidney injury.Bioscience reports · 2022Article
- A Machine Learning Model for Accurate Prediction of Sepsis in ICU Patients.Frontiers in public health · 2021Observational
- Dihydromyricetin improves vascular hyporesponsiveness in experimental sepsis via attenuating the over-excited MaxiK and KPharmaceutical biology · 2018Article
- GTS-21 Protected Against LPS-Induced Sepsis Myocardial Injury in Mice Through α7nAChR.Inflammation · 2018Article
- Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice.International journal of experimental pathology · 2017Article
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Deletion of Nlrp3 Augments Survival during Polymicrobial Sepsis by Decreasing Autophagy and Enhancing Phagocytosis.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- A Protective Role of Glibenclamide in Inflammation-Associated Injury.Mediators of inflammation · 2017Review
- Inhibition of IκB Kinase Attenuates the Organ Injury and Dysfunction Associated with Hemorrhagic Shock.Molecular medicine (Cambridge, Mass.) · 2015Article
- Fluid resuscitation therapy in endotoxemic hamsters improves survival and attenuates capillary perfusion deficits and inflammatory responses by a mechanism related to nitric oxide.Journal of translational medicine · 2014Article
- Anti-nociceptive and anti-edematogenic effects of glibenclamide in a model of acute gouty attack in rats.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThere is increasing evidence that potassium channels are involved in the cardiovascular dysfunction of sepsis. This evidence was obtained after the systemic inflammation, cardiovascular dysfunction and organ damage had developed. Here we have studied the consequences of early interference with potassium channels on development of sepsis. EXPERIMENTAL APPROACH: Sepsis was induced by caecal ligation and puncture (CLP) or sham surgery in Wistar rats. Four hours after surgery, animals received tetraethylammonium (TEA; a non-selective potassium channel blocker) or glibenclamide (a selective ATP-sensitive potassium channel blocker). Twenty-four hours after surgery, inflammatory, biochemical, haemodynamic parameters and survival were evaluated. KEY
resultsSepsis significantly increased plasma NO(x) levels, expression of inducible nitric oxide synthase (NOS-2) protein in lung and thigh skeletal muscle, lung myeloperoxidase, urea, creatinine and lactate levels, TNF-α and IL-1β, hypotension and hyporesponsiveness to phenylephrine and hyperglycemia followed by hypoglycemia. TEA injected 4 h after surgery attenuated the increased NOS-2 expression, reduced plasma NO(x) , lung myeloperoxidase activity, levels of TNF-α and IL-1β, urea, creatinine and lactate levels, prevented development of hypotension and hyporesponsiveness to phenylephrine, the alterations in plasma glucose and reduced late mortality by 50%. Glibenclamide did not improve any of the measured parameters and increased mortality rate, probably due to worsening the hypoglycemic phase of sepsis. CONCLUSIONS AND IMPLICATIONS: Early blockade of TEA-sensitive (but not the ATP-sensitive subtype) potassium channels reduced organ damage and mortality in experimental sepsis. This beneficial effect seems to be, at least in part, due to reduction in NOS-2 expression.
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