Trial reportJournal of the American Geriatrics Society2011
Geriatric conditions, medication use, and risk of adverse drug events in a predominantly male, older veteran population.
Trial report in Journal of the American Geriatrics Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- A descriptive analysis of drug-drug interactions and corresponding adverse drug reactions in multimorbid older inpatients: findings from the SENATOR trial.European geriatric medicine · 2024Trial
- A patient-centered deprescribing intervention for hospitalized older patients with polypharmacy: rationale and design of the Shed-MEDS randomized controlled trial.BMC health services research · 2019Article
- Improving Care Transitions for Hospitalized Veterans Discharged to Skilled Nursing Facilities: A Focus on Polypharmacy and Geriatric Syndromes.Geriatrics (Basel, Switzerland) · 2019Article
- Polypharmacy in the Geriatric Oncology Population.Current oncology reports · 2017Review
- External validation of the Vulnerable Elder's Survey for predicting mortality and emergency admission in older community-dwelling people: a prospective cohort study.BMC geriatrics · 2017Article
- Implementation of integrated geriatric care at a German hospital: a case study to understand when and why beneficial outcomes can be achieved.BMC health services research · 2017Article
- Stability of Geriatric Syndromes in Hospitalized Medicare Beneficiaries Discharged to Skilled Nursing Facilities.Journal of the American Geriatrics Society · 2016Article
- Drug-drug interactions and adverse drug reactions in polypharmacy among older adults: an integrative review.Revista latino-americana de enfermagem · 2016Review
- Use of Renally Inappropriate Medications in Older Veterans: A National Study.Journal of the American Geriatrics Society · 2015Article
- Reduction of patient-reported antidepressant side effects, by type of collaborative care.Psychiatric services (Washington, D.C.) · 2015Article
- The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML).Leukemia research · 2014Article
- Influence of patient age and comorbid burden on clinician attitudes toward heart failure guidelines.The American journal of geriatric pharmacotherapy · 2012Article
- Geriatric conditions and the risk of adverse drug reactions in older adults: a review.Drug safety · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo determine whether geriatric conditions and functional impairment are independent risk factors for adverse drug events (ADEs).
designProspective cohort study.
settingVeterans Affairs Medical Center.
participantsThree hundred seventy-seven veterans aged 65 and older and taking five or more medications. MEASUREMENTS: Geriatric conditions and functional status were assessed using participant interviews and structured assessments at study baseline. ADEs were elicited during participant interviews 3 and 12 months after study enrollment using validated methods.
resultsThe strong majority (97%) of participants were male, with a mean age of 74 ± 5; 123 (33%) had one or more dependencies in instrumental activities of daily living (IADLs). Over the 1-year study period, 126 participants (33%) developed 167 ADEs. Upon multivariable analysis, risk of ADEs was not associated with any of the geriatric conditions that there was sufficient power to evaluate, including IADL function, cognitive impairment, depression, visual impairment, incontinence, constipation, and a summative measure of geriatric burden comprising the above and history of falls or gait instability. In exploratory analyses, the strongest factor associated with ADEs was the number of drugs added to a participant's medication regimen during the 1-year study period (incidence rate ratio 1.11 per each added drug, 95% confidence interval=1.03-1.19).
conclusionCommon geriatric conditions and IADL function were not associated with ADEs in a predominantly male, older veteran population. Although it is important to consider the unique circumstances of each participant, excessive caution in prescribing to older adults with these geriatric conditions may not be warranted.
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