ArticleJournal of aerosol medicine and pulmonary drug delivery2011
Improving the lung delivery of nasally administered aerosols during noninvasive ventilation-an application of enhanced condensational growth (ECG).
Article in Journal of aerosol medicine and pulmonary drug delivery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Rapid and Efficient Aerosol Delivery During 60 L/min High Flow Nasal Cannula Therapy-In Vitro Development of a Novel Dry Powder Delivery Platform.AAPS PharmSciTech · 2026Article
- Influencing factors of particle deposition in the human nasal cavity.Laryngoscope investigative otolaryngology · 2024Review
- Septoplasty Effect on the Enhancement of Airflow Distribution and Particle Deposition in Nasal Cavity: A Numerical Study.Healthcare (Basel, Switzerland) · 2022Article
- Inter-species Variabilities of Droplet Transport, Size Change, and Deposition in Human and Rat Respiratory Systems: AnJournal of aerosol science · 2021Article
- High-Efficiency Dry Powder Aerosol Delivery to Children: Review and Application of New Technologies.Journal of aerosol science · 2021Article
- CFD Guided Optimization of Nose-to-Lung Aerosol Delivery in Adults: Effects of Inhalation Waveforms and Synchronized Aerosol Delivery.Pharmaceutical research · 2020Article
- Devices for Improved Delivery of Nebulized Pharmaceutical Aerosols to the Lungs.Journal of aerosol medicine and pulmonary drug delivery · 2019Review
- Differences in Particle Deposition Between Members of Imaging-Based Asthma Clusters.Journal of aerosol medicine and pulmonary drug delivery · 2019Article
- Use of computational fluid dynamics deposition modeling in respiratory drug delivery.Expert opinion on drug delivery · 2019Review
- Efficient Nose-to-Lung Aerosol Delivery with an Inline DPI Requiring Low Actuation Air Volume.Pharmaceutical research · 2018Article
- Application of an inline dry powder inhaler to deliver high dose pharmaceutical aerosols during low flow nasal cannula therapy.International journal of pharmaceutics · 2018Article
- Aerosol Drug Delivery During Noninvasive Positive Pressure Ventilation: Effects of Intersubject Variability and Excipient Enhanced Growth.Journal of aerosol medicine and pulmonary drug delivery · 2017Article
- Absorption and Clearance of Pharmaceutical Aerosols in the Human Nose: Development of a CFD Model.Journal of aerosol medicine and pulmonary drug delivery · 2016Article
- Efficient Nose-to-Lung (N2L) Aerosol Delivery with a Dry Powder Inhaler.Journal of aerosol medicine and pulmonary drug delivery · 2015Article
- Variability in Nose-to-Lung Aerosol Delivery.Journal of aerosol science · 2014Article
- Development of high efficiency ventilation bag actuated dry powder inhalers.International journal of pharmaceutics · 2014Article
- Targeted Lung Delivery of Nasally Administered Aerosols.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2014Article
- The use of condensational growth methods for efficient drug delivery to the lungs during noninvasive ventilation high flow therapy.Pharmaceutical research · 2013Article
- High-efficiency generation and delivery of aerosols through nasal cannula during noninvasive ventilation.Journal of aerosol medicine and pulmonary drug delivery · 2013Article
- Improving pharmaceutical aerosol delivery during noninvasive ventilation: effects of streamlined components.Annals of biomedical engineering · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundAerosol drug delivery during noninvasive ventilation (NIV) is known to be inefficient due to high depositional losses. To improve drug delivery efficiency, the concept of enhanced condensational growth (ECG) was recently proposed in which a submicrometer or nanoaerosol reduces extrathoracic deposition and subsequent droplet size increase promotes lung retention. The objective of this study was to provide proof-of-concept that the ECG approach could improve lung delivery of nasally administered aerosols under conditions consistent with NIV.
methodsAerosol deposition and size increase were evaluated in an adult nose-mouth-throat (NMT) replica geometry using both in vitro experiments and CFD simulations. For the ECG delivery approach, separate streams of a submicrometer aerosol and warm (39°C) saturated air were generated and delivered to the right and left nostril inlets, respectively. A control case was also considered in which an aerosol with a mass median aerodynamic diameter (MMAD) of 4.67 μm was delivered to the model.
resultsIn vitro experiments showed that the ECG approach significantly reduced the drug deposition fraction in the NMT geometry compared with the control case [14.8 (1.83)%-ECG vs. 72.6 (3.7)%-control]. Aerosol size increased from an initial MMAD of 900 nm to a size of approximately 2 μm at the exit of the NMT geometry. Results of the CFD model were generally in good agreement with the experimental findings. Based on CFD predictions, increasing the delivery temperature of the aerosol stream from 21 to 35°C under ECG conditions further reduced the total NMT drug deposition to 5% and maintained aerosol growth by ECG to approximately 2 μm.
conclusionsApplication of the ECG approach may significantly improve the delivery of pharmaceutical aerosols during NIV and may open the door for using the nasal route to routinely deliver pulmonary medications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.