ArticleJournal of muscle research and cell motility1990
Systematic variation in myosin expression along extraocular muscle fibres of the adult rat.
Article in Journal of muscle research and cell motility, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 97 citations in OpenAlex.
- Developmental, Physiological and Phylogenetic Perspectives on the Expression and Regulation of Myosin Heavy Chains in Craniofacial Muscles.International journal of molecular sciences · 2024Review
- Neuroprotective Effect of Vascular Endothelial Growth Factor on Motoneurons of the Oculomotor System.International journal of molecular sciences · 2021Review
- The ancient sarcomeric myosins found in specialized muscles.Skeletal muscle · 2019Review
- Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis.Acta neuropathologica · 2017Review
- Adaptability of the Immature Ocular Motor Control System: Unilateral IGF-1 Medial Rectus Treatment.Investigative ophthalmology & visual science · 2015Article
- Adaptation of slow myofibers: the effect of sustained BDNF treatment of extraocular muscles in infant nonhuman primates.Investigative ophthalmology & visual science · 2015Article
- Complex tropomyosin and troponin T isoform expression patterns in orbital and global fibers of adult dog and rat extraocular muscles.Journal of muscle research and cell motility · 2013Article
- A continuum of myofibers in adult rabbit extraocular muscle: force, shortening velocity, and patterns of myosin heavy chain colocalization.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Pitx2 regulates myosin heavy chain isoform expression and multi-innervation in extraocular muscle.The Journal of physiology · 2011Article
- The continuum of hybrid IIX/IIB fibers in normal mouse muscles: MHC isoform proportions and spatial distribution within single fibers.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Myosin heavy chain expression in mouse extraocular muscle: more complex than expected.Investigative ophthalmology & visual science · 2010Article
- Effects of elevated thyroid hormone on adult rabbit extraocular muscles.Investigative ophthalmology & visual science · 2010Article
- Histochemical and immunohistochemical profile of human and rat ocular medial rectus muscles.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2009Article
- Fibre types and myosin heavy chain expression in the ocular medial rectus muscle of the adult rat.Journal of muscle research and cell motility · 2000Article
- Complex three-dimensional patterns of myosin isoform expression: differences between and within specific extraocular muscles.Journal of muscle research and cell motility · 1999Article
- Contractile activation characteristics of single permeabilized fibres from levator palpebrae superioris, orbicularis oculi and vastus lateralis muscles from humans.The Journal of physiology · 1999Article
- Spatial and temporal patterns of myosin heavy chain expression in developing rat extraocular muscle.Journal of muscle research and cell motility · 1996Article
- Expression of extraocular myosin heavy chain in rabbit laryngeal muscle.Journal of muscle research and cell motility · 1995Article
- An immunocytochemical marker for early type I muscle fibers in the developing rat hindlimb.Anatomy and embryology · 1995Article
- Identification of alpha-cardiac myosin heavy chain mRNA and protein in extraocular muscle of the adult rabbit.Journal of muscle research and cell motility · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Monoclonal antibodies (McAB) specific for fast (C14) and slow (S58) myosin, and a myosin antigenically similar to neonatal/embryonic myosin in mammals (ALD180), were used to characterize the myosin distribution in orbital layer fibres of rat extraocular muscles (EOM) in relation to innervation patterns. The orbital layer is composed of both singly-innervated (SIF) and multiply-innervated (MIF) fibres. The SIFs have the characteristics of twitch fibres, while the MIFs, in addition to possessing many small endings characteristic of tonic fibres, also have an en-plaque-like innervation in the endplate band resembling that of the adjacent SIFs. Myosin expression in MIFs and SIFs is unusual and varies systematically along the length of the fibres. Both SIFs and MIFs label with ALD180, but this labelling is absent in both fibre types in the endplate band region, where all fibres label with C14. Distally and also proximally to the endplate band, SIFs label with both ALD180 and C14, while the MIFs, innervated by many small, superficial endings in these regions, label with ALD180 only. This pattern of myosin expression could also be demonstrated in isolated fibres. The results are discussed in relation to the hypothesis that both populations of orbital layer fibres express constitutively both fast and the neonatal-like myosin, and that superimposed on this constitutive expression twitch or tonic innervation acts locally to selectively suppress either neonatal-like or fast myosin, respectively.
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Registered trials
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