ReviewEuropean archives of psychiatry and clinical neuroscience2011
Neuropsychological endophenotypes in attention-deficit/hyperactivity disorder: a review of genetic association studies.
Review in European archives of psychiatry and clinical neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Caffeine Consumption on Attention Deficit Hyperactivity Disorder (ADHD) Treatment: A Systematic Review of Animal Studies.Nutrients · 2022Pooled it
- Long-term functional outcome in adult prison inmates with ADHD receiving OROS-methylphenidate.European archives of psychiatry and clinical neuroscience · 2012Trial
- Review
- Neurodevelopmental disorders and gut-brain interactions: exploring the therapeutic potential of pycnogenol through microbial-metabolic-neural networks.Frontiers in cellular and infection microbiology · 2025Review
- Genetics in the ADHD Clinic: How Can Genetic Testing Support the Current Clinical Practice?Frontiers in psychology · 2022Review
- Associations Among Internet Addiction, Genetic Polymorphisms, Family Functioning, and Psychopathological Risk: Cross-Sectional Exploratory Study.JMIR mental health · 2020Article
- ADHD: Current Concepts and Treatments in Children and Adolescents.Neuropediatrics · 2020Review
- Brain Network Connectivity and Association with Catechol-O-Methyltransferase Gene Polymorphism in Korean Attention-Deficit Hyperactivity Disorder Children.Psychiatry investigation · 2020Article
- Heterosis in COMT Val158Met Polymorphism Contributes to Sex-Differences in Children's Math Anxiety.Frontiers in psychology · 2019Article
- COMT and DAT1 polymorphisms moderate the indirect effect of parenting behavior on youth ADHD symptoms through neurocognitive functioning.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2018Article
- Timing Deficits in ADHD: Insights From the Neuroscience of Musical Rhythm.Frontiers in computational neuroscience · 2018Article
- Interaction effects ofBrain and behavior · 2017Article
- Testing for the mediating role of endophenotypes using molecular genetic data in a twin study of ADHD traits.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Article
- The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts.Human molecular genetics · 2016Article
- Satiety and the Self-Regulation of Food Take in Children: a Potential Role for Gene-Environment Interplay.Current obesity reports · 2016Review
- PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research.EMBO molecular medicine · 2015Article
- A 40-bp VNTR polymorphism in the 3'-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism.Behavioral and brain functions : BBF · 2015Article
- Associations between catecholaminergic, GABAergic, and serotonergic genes and self-reported attentional function in oncology patients and their family caregivers.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2015Article
- Hardy-Weinberg equilibrium analysis of the 48 bp VNTR in the III exon of the DRD4 gene in a sample of parents of ADHD cases.The application of clinical genetics · 2015Article
- Biomarkers in the diagnosis of ADHD--promising directions.Current psychiatry reports · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a relatively large body of research has been published up to now, it may be informative to explore whether the use of endophenotypes has produced consistent findings in attention-deficit hyperactivity disorder (ADHD). We reviewed the results of genetic studies investigating associations between putative susceptibility genes for ADHD and neuropsychological traits relevant for this disorder. A PubMed database search identified 47 studies. Most of them (n = 36) examined a single candidate gene, while seven studies examined two or three genes and only four studies examined 10 genes or more. The most investigated genes were DRD4, DAT1, COMT, MAOA, and DBH. Regarding DRD4, association of high reaction time variability with the 7-R allele absence appears to be the most consistent result. Speed of processing, set shifting, and cognitive impulsiveness were less frequently investigated, but seem to be altered in the 7-R allele carriers. Regarding DAT1, majority of studies reported negative results indicating that this gene may have a modulating effect rather than direct influence on cognitive functioning. The other genes were investigated in fewer studies, and the reported findings need to be replicated. The principal methodological issues that could represent confounding factors and may explain conflicting results are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.