ArticleThe review of diabetic studies : RDS2010
German new onset diabetes in the young incident cohort study: DiMelli study design and first-year results.
Article in The review of diabetic studies : RDS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Presymptomatic type 1 diabetes and disease severity at onset. Reply to Schneider J, Gemulla G, Kiess W et al [letter].Diabetologia · 2023Article
- Children diagnosed with presymptomatic type 1 diabetes through public health screening have milder diabetes at clinical manifestation.Diabetologia · 2023Article
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- Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes.Clinical epigenetics · 2020Article
- Cytoplasmic ends of tetraspanin 7 harbour epitopes recognised by autoantibodies in type 1 diabetes.Diabetologia · 2019Article
- Clinical and research uses of genetic risk scores in type 1 diabetes.Current opinion in genetics & development · 2018Review
- Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young.Pediatric diabetes · 2018Article
- miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Incomplete immune response to coxsackie B viruses associates with early autoimmunity against insulin.Scientific reports · 2016Article
- Tetraspanin 7 autoantibodies in type 1 diabetes.Diabetologia · 2016Article
- Article
- Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes.Diabetologia · 2014Article
- Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression.Diabetologia · 2014Article
- Article
- Does diabetes appear in distinct phenotypes in young people? Results of the diabetes mellitus incidence Cohort Registry (DiMelli).PloS one · 2013Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
backgroundDiabetes incidence in childhood and youth is increasing worldwide, including autoimmune and non-autoimmune cases. Recent findings suggest that there is a larger than expected proportion of type 2 diabetes in youth, and potential cases of intermediate diabetes phenotypes. Most pediatric diabetes registries focus on type 1 diabetes. Also, there is an absence of reliable data on type 2 diabetes incidence in youth.
aimsThe DiMelli study aims to establish a diabetes incidence cohort registry of patients in Germany, diagnosed with diabetes mellitus before age 20 years. It will be used to characterize diabetes phenotypes by immunologic, metabolic, and genetic markers. DiMelli will assess the contribution of obesity and socio-demographic factors to the development of diabetes in childhood and youth.
methodsRecruitment of patients started in 2009, and is expected to continue at a rate of 250 patients per year.
results84% of the 216 patients recruited within the first year were positive for multiple islet autoantibodies, 12% for one islet autoantibody, and 4% were islet autoantibody-negative. Patients with multiple islet autoantibodies were younger and had lower fasting C-peptide levels, compared to islet autoantibody-negative patients (median age 10.0 vs. 14.1 years, p < 0.01).
conclusionsResults from the first year of the study show that DiMelli will help to reveal new knowledge on the etiology of diabetes, and the contribution of genetic predisposition and environmental risk factors to the different types of diabetes.
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