ArticlePloS one2011
Risk factors of Streptococcus suis infection in Vietnam. A case-control study.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 68 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 5 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Molecular Epidemiology of Underreported Emerging Zoonotic Pathogen Streptococcus suis in Europe.Emerging infectious diseases · 2024Pooled it
- Review of the aetiologies of central nervous system infections in Vietnam.Frontiers in public health · 2024Pooled it
- Risk factors for Streptococcus suis infection: A systematic review and meta-analysis.Scientific reports · 2018Pooled it
- Streptococcus suis Meningitis: A Systematic Review and Meta-analysis.PLoS neglected tropical diseases · 2015Pooled it
- Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans.Emerging infectious diseases · 2014Pooled it
- Article
- Innate immune response to Streptococcus suis infection: advances and future challenges.Veterinary research · 2026Review
- Non-penicillin -susceptible and linezolid-non-susceptible Streptococcus suis clonal complex 233 from humans.Scientific reports · 2026Article
- Pyogenic Spondylitis with Epidural Abscess Caused byPathogens (Basel, Switzerland) · 2026Article
- Article
- Evaluating the Diagnostic Utility of 16S Oxford Nanopore Technology Sequencing in Patients With Central Nervous System Infections and Its Usefulness in Antimicrobial Stewardship.The Journal of infectious diseases · 2025Article
- Article
- Streptococcus suis-Associated Meningitis in a Southern Region of Vietnam.The American journal of tropical medicine and hygiene · 2024Article
- Study on the Effect of Phillyrin onBiomolecules · 2024Article
- Optimization of the Diagnosis of Central Nervous System Infections in Vietnamese Hospitals: Results From a Retrospective Multicenter Study.Open forum infectious diseases · 2024Article
- Translocation across a human enteroid monolayer by zoonoticiScience · 2024Article
- Identification of plasminogen-binding sites inFrontiers in cellular and infection microbiology · 2024Article
- Screening ofVeterinary world · 2024Article
- Epidemiology and genetic diversity of Streptococcus suis in smallhold swine farms in the Philippines.Scientific reports · 2023Article
- The spatio-temporal distribution of acute encephalitis syndrome and its association with climate and landcover in Vietnam.BMC infectious diseases · 2023Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedHoang, Truong [removed]; Campbell, James [removed]; multiple author names corrected
- Erratum issuedTruong, Hoang [added]; Campbell, James [added].
Authors and funding
38 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundStreptococcus suis infection, an emerging zoonosis, is an increasing public health problem across South East Asia and the most common cause of acute bacterial meningitis in adults in Vietnam. Little is known of the risk factors underlying the disease. METHODS AND
findingsA case-control study with appropriate hospital and matched community controls for each patient was conducted between May 2006 and June 2009. Potential risk factors were assessed using a standardized questionnaire and investigation of throat and rectal S. suis carriage in cases, controls and their pigs, using real-time PCR and culture of swab samples. We recruited 101 cases of S. suis meningitis, 303 hospital controls and 300 community controls. By multivariate analysis, risk factors identified for S. suis infection as compared to either control group included eating "high risk" dishes, including such dishes as undercooked pig blood and pig intestine (OR(1) = 2.22; 95%CI = [1.15-4.28] and OR(2) = 4.44; 95%CI = [2.15-9.15]), occupations related to pigs (OR(1) = 3.84; 95%CI = [1.32-11.11] and OR(2) = 5.52; 95%CI = [1.49-20.39]), and exposures to pigs or pork in the presence of skin injuries (OR(1) = 7.48; 95%CI = [1.97-28.44] and OR(2) = 15.96; 95%CI = [2.97-85.72]). S. suis specific DNA was detected in rectal and throat swabs of 6 patients and was cultured from 2 rectal samples, but was not detected in such samples of 1522 healthy individuals or patients without S. suis infection.
conclusionsThis case control study, the largest prospective epidemiological assessment of this disease, has identified the most important risk factors associated with S. suis bacterial meningitis to be eating 'high risk' dishes popular in parts of Asia, occupational exposure to pigs and pig products, and preparation of pork in the presence of skin lesions. These risk factors can be addressed in public health campaigns aimed at preventing S. suis infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.