ArticlePloS one2011
Induction of cell stress in neurons from transgenic mice expressing yellow fluorescent protein: implications for neurodegeneration research.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- In Vivo Nanodiamond Quantum Sensing of Free Radicals in Caenorhabditis elegans Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Defective Mammary Epithelial Outgrowth in Transgenic EKAREV-NLS Mice: Correction via Estrogen Supplementation and Genetic Background Modification.Journal of mammary gland biology and neoplasia · 2025Article
- Aging alters mechanisms underlying voluntary movements in spinal motor neurons of mice, primates, and humans.JCI insight · 2023Article
- Article
- Transgenic models for investigating the nervous system: Currently available neurofluorescent reporters and potential neuronal markers.Biochimica et biophysica acta. General subjects · 2020Review
- Cochlea-Specific Deletion of CaFrontiers in cellular neuroscience · 2019Article
- A Brief History of Microglial Ultrastructure: Distinctive Features, Phenotypes, and Functions Discovered Over the Past 60 Years by Electron Microscopy.Frontiers in immunology · 2018Review
- Activity-dependent degeneration of axotomized neuromuscular synapses in Wld S mice.Neuroscience · 2015Article
- Long-term correction of biochemical and neurological abnormalities in MLD mice model by neonatal systemic injection of an AAV serotype 9 vector.Gene therapy · 2014Article
- Green fluorescent protein expression triggers proteome changes in breast cancer cells.Experimental cell research · 2014Article
- Diffuse traumatic axonal injury in the optic nerve does not elicit retinal ganglion cell loss.Journal of neuropathology and experimental neurology · 2013Article
- dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration.PloS one · 2013Article
- Retrograde and Wallerian axonal degeneration occur synchronously after retinal ganglion cell axotomy.The American journal of pathology · 2012Article
- Calcium dependence of damage to mouse motor nerve terminals following oxygen/glucose deprivation.Experimental neurology · 2012Article
- Absence of SOD1 leads to oxidative stress in peripheral nerve and causes a progressive distal motor axonopathy.Experimental neurology · 2012Article
- Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model.Nature communications · 2012Article
- Article
- Optogenetic reporters: Fluorescent protein-based genetically encoded indicators of signaling and metabolism in the brain.Progress in brain research · 2012Review
- ApoE isoform-specific regulation of regeneration in the peripheral nervous system.Human molecular genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMice expressing fluorescent proteins in neurons are one of the most powerful tools in modern neuroscience research and are increasingly being used for in vivo studies of neurodegeneration. However, these mice are often used under the assumption that the fluorescent proteins present are biologically inert. METHODOLOGY/PRINCIPAL
findingsHere, we show that thy1-driven expression of yellow fluorescent protein (YFP) in neurons triggers multiple cell stress responses at both the mRNA and protein levels in vivo. The presence of YFP in neurons also subtly altered neuronal morphology and modified the time-course of dying-back neurodegeneration in experimental axonopathy, but not in Wallerian degeneration triggered by nerve injury. CONCLUSIONS/SIGNIFICANCE: We conclude that fluorescent protein expressed in thy1-YFP mice is not biologically inert, modifies molecular and cellular characteristics of neurons in vivo, and has diverse and unpredictable effects on neurodegeneration pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.