ArticlePLoS neglected tropical diseases2011
Neuropathic pain and psychological morbidity in patients with treated leprosy: a cross-sectional prevalence study in Mumbai.
Article in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 73 citations in OpenAlex.
- Treatment of neuropathic pain in leprosy patients with a physiotherapeutic protocol combined with photobiomodulation.Lasers in medical science · 2025Trial
- Addressing multimorbidity in Leprosy: A retrospective chart review from India.PLoS neglected tropical diseases · 2026Article
- Exploring the Neurological Manifestations of Leprosy: Clinical Insights and Implications.Cureus · 2025Review
- The Neurological Impact of Leprosy: Manifestations and Treatment Approaches.Neurology international · 2024Review
- Understanding leprosy reactions and the impact on the lives of people affected: An exploration in two leprosy endemic countries.PLoS neglected tropical diseases · 2022Article
- Treatment and Evaluation Advances in Leprosy Neuropathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Perception of cure among leprosy patients post completion of multi-drug therapy.BMC infectious diseases · 2021Article
- Assessment of neuropathic pain in leprosy patients with relapse or treatment failure by infrared thermography: A cross-sectional study.PLoS neglected tropical diseases · 2021Article
- Burden of depression and anxiety among leprosy affected and associated factors-A cross sectional study from India.PLoS neglected tropical diseases · 2021Article
- The impact of leprosy on the mental wellbeing of leprosy-affected persons and their family members - a systematic review.Global mental health (Cambridge, England) · 2020Review
- Cytokine Levels in Neural Pain in Leprosy.Frontiers in immunology · 2020Article
- Article
- Diagnosis and impact of neuropathic pain in leprosy patients in Nepal after completion of multidrug therapy.PLoS neglected tropical diseases · 2018Article
- Clinical and Neurophysiological Features of Leprosy Patients with Neuropathic Pain.The American journal of tropical medicine and hygiene · 2018Article
- Coexistence of Nerve Enlargement and Neuratrophy Detected by Ultrasonography in Leprosy Patients.Scientific reports · 2018Article
- Neuropathic pain in leprosy: symptom profile characterization and comparison with neuropathic pain of other etiologies.Pain reports · 2018Article
- Investigating the validity of the DN4 in a consecutive population of patients with chronic pain.PloS one · 2017Article
- Agreement Between the Douleur Neuropathique in 4 Questions and Leeds Assessment of Neuropathic Symptoms and Signs Questionnaires to Classify Neuropathic Pain Among Patients with Leprosy.The American journal of tropical medicine and hygiene · 2016Article
- Diagnosis and medical treatment of neuropathic pain in leprosy.Revista latino-americana de enfermagem · 2016Article
- Pain and quality of life in leprosy patients in an endemic area of Northeast Brazil: a cross-sectional study.Infectious diseases of poverty · 2016Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuropathic pain has been little studied in leprosy. We assessed the prevalence and clinical characteristics of neuropathic pain and the validity of the Douleur Neuropathique 4 questionnaire as a screening tool for neuropathic pain in patients with treated leprosy. The association of neuropathic pain with psychological morbidity was also evaluated. METHODOLOGY/PRINCIPAL
findingsAdult patients who had completed multi-drug therapy for leprosy were recruited from several Bombay Leprosy Project clinics. Clinical neurological examination, assessment of leprosy affected skin and nerves and pain evaluation were performed for all patients. Patients completed the Douleur Neuropathique 4 and the 12-item General Health Questionnaire to identify neuropathic pain and psychological morbidity. CONCLUSIONS/SIGNIFICANCE: One hundred and one patients were recruited, and 22 (21.8%) had neuropathic pain. The main sensory symptoms were numbness (86.4%), tingling (68.2%), hypoesthesia to touch (81.2%) and pinprick (72.7%). Neuropathic pain was associated with nerve enlargement and tenderness, painful skin lesions and with psychological morbidity. The Douleur Neuropathique 4 had a sensitivity of 100% and specificity of 92% in diagnosing neuropathic pain. The Douleur Neuropathique 4 is a simple tool for the screening of neuropathic pain in leprosy patients. Psychological morbidity was detected in 15% of the patients and 41% of the patients with neuropathic pain had psychological morbidity.
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