ArticlePloS one2011
Drug inhibition profile prediction for NFκB pathway in multiple myeloma.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Review
- Clinical and biological significance ofCancer biology & therapy · 2020Article
- Controlling Nuclear NF-κB Dynamics by β-TrCP-Insights from a Computational Model.Biomedicines · 2019Article
- Predicting Drug Combination Index and Simulating the Network-Regulation Dynamics by Mathematical Modeling of Drug-Targeted EGFR-ERK Signaling Pathway.Scientific reports · 2017Article
- Mathematical and Computational Modeling in Complex Biological Systems.BioMed research international · 2017Review
- Modeling of signaling crosstalk-mediated drug resistance and its implications on drug combination.Oncotarget · 2016Article
- Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success.Annals of biomedical engineering · 2016Review
- Functional genomics screen identifies YAP1 as a key determinant to enhance treatment sensitivity in lung cancer cells.Oncotarget · 2016Article
- Prediction of treatment efficacy for prostate cancer using a mathematical model.Scientific reports · 2016Article
- Computational systems biology in cancer brain metastasis.Frontiers in bioscience (Scholar edition) · 2016Review
- Systemic modeling myeloma-osteoclast interactions under normoxic/hypoxic condition using a novel computational approach.Scientific reports · 2015Article
- Article
- Characterization of p38 MAPK isoforms for drug resistance study using systems biology approach.Bioinformatics (Oxford, England) · 2014Article
- Partial inhibition and bilevel optimization in flux balance analysis.BMC bioinformatics · 2013Article
- Multi-scale agent-based modeling on melanoma and its related angiogenesis analysis.Theoretical biology & medical modelling · 2013Article
- PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells.Carcinogenesis · 2013Article
- Signalling by protein phosphatases and drug development: a systems-centred view.The FEBS journal · 2013Review
- Cytokine combination therapy prediction for bone remodeling in tissue engineering based on the intracellular signaling pathway.Biomaterials · 2012Article
- Multi-scale agent-based brain cancer modeling and prediction of TKI treatment response: incorporating EGFR signaling pathway and angiogenesis.BMC bioinformatics · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Nuclear factor κB (NFκB) activation plays a crucial role in anti-apoptotic responses in response to the apoptotic signaling during tumor necrosis factor (TNFα) stimulation in Multiple Myeloma (MM). Although several drugs have been found effective for the treatment of MM by mainly inhibiting NFκB pathway, there are not any quantitative or qualitative results of comparison assessment on inhibition effect between different drugs either used alone or in combinations. Computational modeling is becoming increasingly indispensable for applied biological research mainly because it can provide strong quantitative predicting power. In this study, a novel computational pathway modeling approach is employed to comparably assess the inhibition effects of specific drugs used alone or in combinations on the NFκB pathway in MM and to predict the potential synergistic drug combinations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.