ArticlePloS one2011
Reactive oxygen species scavenging by catalase is important for female Lutzomyia longipalpis fecundity and mortality.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 96 citations in OpenAlex.
- Catalases act as putative oral secretion effectors in Tuta absoluta, suppressing tomato oxidative defenses and providing safe RNAi targets for pest control.Pest management science · 2026Article
- Peroxisomes in the mouse ovary and their alterations during follicular development and oocyte maturation.Cell and tissue research · 2025Article
- Article
- Identification and characterization of catalase genes involved in the response to heat stress in Tetranychus urticae (Acari: Tetranychidae).BMC genomics · 2025Article
- Stress in dipteran insects mass-reared for sterile insect technique applications.Insect science · 2025Review
- Article
- Enzymatic, cellular breakdown and lysis in treatment of Beauveria Brongniartii on Spodoptera litura (Fabricius, 1775).Scientific reports · 2025Article
- Research on the Expression of Immune-Related Genes at Different Stages in the Third-Instar Larvae ofInsects · 2025Article
- Warmer temperature accelerates reproductive senescence in mosquitoes.Frontiers in physiology · 2025Article
- The complexities of blood-feeding patterns in mosquitoes and sandflies and the burden of disease: A minireview.Veterinary medicine and science · 2024Review
- Interactions between Leishmania parasite and sandfly: a review.Parasitology research · 2023Review
- Differential Participation of Plant Ribosomal Proteins from the Small Ribosomal Subunit in Protein Translation under Stress.Biomolecules · 2023Article
- RNAi-mediated gene silencing ofFrontiers in physiology · 2023Article
- Genomic analyses provide insights into the genome evolution and environmental adaptation of the tobacco mothFrontiers in physiology · 2023Article
- Assessment of Sex-Specific Toxicity and Physiological Responses to Thymol in a Common Bean PestFrontiers in physiology · 2022Article
- Catalase impairsVirulence · 2021Article
- Bayesian compartmental models and associated reproductive numbers for an infection with multiple transmission modes.Biometrics · 2020Article
- Article
- Biochemical and Functional Characterization of Glycoside Hydrolase Family 16 Genes inFrontiers in physiology · 2019Article
- Transmission blocking sugar baits for the control of Leishmania development inside sand flies using environmentally friendly beta-glycosides and their aglycones.Parasites & vectors · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phlebotomine sand fly Lutzomyia longipalpis is the most important vector of American visceral leishmaniasis (AVL), the disseminated and most serious form of the disease in Central and South America. In the natural environment, most female L. longipalpis are thought to survive for less than 10 days and will feed on blood only once or twice during their lifetime. Successful transmission of parasites occurs when a Leishmania-infected female sand fly feeds on a new host. Knowledge of factors affecting sand fly longevity that lead to a reduction in lifespan could result in a decrease in parasite transmission. Catalase has been found to play a major role in survival and fecundity in many insect species. It is a strong antioxidant enzyme that breaks down toxic reactive oxygen species (ROS). Ovarian catalase was found to accumulate in the developing sand fly oocyte from 12 to 48 hours after blood feeding. Catalase expression in ovaries as well as oocyte numbers was found to decrease with age. This reduction was not found in flies when fed on the antioxidant ascorbic acid in the sugar meal, a condition that increased mortality and activation of the prophenoloxidase cascade. RNA interference was used to silence catalase gene expression in female Lu. longipalpis. Depletion of catalase led to a significant increase of mortality and a reduction in the number of developing oocytes produced after blood feeding. These results demonstrate the central role that catalase and ROS play in the longevity and fecundity of phlebotomine sand flies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.