ArticleEuropean journal of human genetics : EJHG2011
The genetic component of human longevity: analysis of the survival advantage of parents and siblings of Italian nonagenarians.
Article in European journal of human genetics : EJHG, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians.International journal of molecular sciences · 2026Review
- Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants.GeroScience · 2026Article
- How Important Are Genes to Achieve Longevity?International journal of molecular sciences · 2022Review
- Protective Effects of Familial Longevity Decrease With Age and Become Negligible for Centenarians.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Nutritional and lifestyle management of the aging journey: A narrative review.Frontiers in nutrition · 2022Review
- Longevity Relatives Count score identifies heritable longevity carriers and suggests case improvement in genetic studies.Aging cell · 2020Article
- Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait.Nature communications · 2019Article
- Longevity Around the Turn of the 20th Century: Life-Long Sustained Survival Advantage for Parents of Today's Nonagenarians.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- The Survival of Spouses Marrying Into Longevity-Enriched Families.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Human longevity: Genetics or Lifestyle? It takes two to tango.Immunity & ageing : I & A · 2016Review
- Extended maternal age at birth of last child and women's longevity in the Long Life Family Study.Menopause (New York, N.Y.) · 2015Article
- Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis.European journal of human genetics : EJHG · 2014Article
- Frailty Index in Europeans: association with determinants of health.Geriatrics & gerontology international · 2014Article
- Cluster analysis to identify elderly people's profiles: a healthcare strategy based on frailty characteristics.Sao Paulo medical journal = Revista paulista de medicina · 2014Article
- The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms.BioMed research international · 2014Review
- MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping.Age (Dordrecht, Netherlands) · 2013Article
- Determinants of exceptional human longevity: new ideas and findings.Vienna yearbook of population research · 2013Article
- Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.Experimental gerontology · 2012Article
- Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity.Immunity & ageing : I & A · 2012Article
- Bitter taste receptor polymorphisms and human aging.PloS one · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Many epidemiological studies have shown that parents, siblings and offspring of long-lived subjects have a significant survival advantage when compared with the general population. However, how much of this reported advantage is due to common genetic factors or to a shared environment remains to be resolved.We reconstructed 202 families of nonagenarians from a population of southern Italy. To estimate the familiarity of human longevity, we compared survival data of parents and siblings of long-lived subjects to that of appropriate Italian birth cohorts. Then, to estimate the genetic component of longevity while minimizing the variability due to environment factors, we compared the survival functions of nonagenarians' siblings with those of their spouses (intrafamily control group).We found that both parents and siblings of the probands had a significant survival advantage over their Italian birth cohort counterparts. On the other hand, although a substantial survival advantage was observed in male siblings of probands with respect to the male intrafamily control group, female siblings did not show a similar advantage. In addition, we observed that the presence of a male nonagenarians in a family significantly decreased the instant mortality rate throughout lifetime for all the siblings; in the case of a female nonagenarians such an advantage persisted only for her male siblings.The methodological approach used here allowed us to distinguish the effects of environmental and genetic factors on human longevity. Our results suggest that genetic factors in males have a higher impact than in females on attaining longevity.
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