Evidence map›Paper›PMID 21407248›Full record

Trial reportEuropean journal of clinical nutrition2011

Cost-effectiveness of a 3-month intervention with oral nutritional supplements in disease-related malnutrition: a randomised controlled pilot study.

K Norman, M Pirlich, C Smoliner, A Kilbert, J D Schulzke, J Ockenga, H Lochs, T Reinhold

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02470013 (Medical and Health Economic Benefit of Oral Nutritional Supplements), which is not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02470013 nacompletednot on this mapstarted 2014, after this paper: background citation

Medical and Health Economic Benefit of Oral Nutritional Supplements (ONS) in Ambulant Patients

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2014 to 2018Enrolled160ConditionsMalnutritionArmsBalanced, energy dense, moderate protein sip feed
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Nutrition support in hospitalised adults at nutritional risk.The Cochrane database of systematic reviews · 2017
    Pooled it
  3. Pooled it
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  14. Review
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  16. Efficacy and Efficiency of Nutritional Support Teams.Journal of clinical medicine · 2019
    Review
  17. Economic Challenges in Nutritional Management.Journal of clinical medicine · 2019
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

K NormanDepartment of Gastroenterology, Hepatology and Endocrinology, Charite-University Medicine, Berlin, Germany. kristina.norman@charite.de
M Pirlich
C Smoliner
A Kilbert
J D Schulzke
J Ockenga
H Lochs
T Reinhold
Charité - Universitätsmedizin Berlin · DEKlinikum Bremen-Mitte · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesNutritional intervention with oral nutritional supplements (ONS) has been shown to increase quality of life in malnourished patients. We investigated whether post-hospital supplementation with ONS is cost-effective according to international benchmarks in malnourished patients. SUBJECTS/

methodsIn total, 114 malnourished patients (50.6±16.1 years, 57 female) with benign gastrointestinal disease were included and randomised to receive either ONS for 3 months and dietary counselling at discharge (intervention, n=60) or only dietary counselling at discharge (control group, n=54). Nutritional status was assessed with Subjective Global Assessment. Intervention patients documented daily intake of ONS; quality of life was assessed with Short-Form (SF)-36 Health Survey and SF-36 values were transformed into health-status utilities. Quality-adjusted life years (QALYs) were calculated by adopting the area under the curve method. We used two different pricing scenarios for ONS (minimum price: [euro]2.30 and maximum: [euro]2.93/tetrapack). The incremental cost-effectiveness ratio (ICER) of supplementation with ONS was calculated for both price scenarios. All analyses were corrected for age and gender.

resultsIntervention patients consumed 2.4±0.8 ONS per day. Intervention and control patients did not differ in their health status utilities at baseline (0.594±0.017 vs 0.619±0.018), but after 3 months, the health status utilities were significantly higher in intervention patients than in control patients (0.731±0.015 vs 0.671±0.016, P=0.028). Intervention was associated with significantly higher costs (ICER: [euro]9497 and [euro]12,099/additional QALY, respectively) but deemed cost-effective according to international thresholds (< [euro]50,000/QALY).

conclusionsA 3-month intervention with ONS increases quality of life in malnourished patients. This treatment appears to be cost-effective according to international benchmarks.

Indexed as

Energy IntakeHealth StatusQuality-Adjusted Life YearsAdultArea Under CurveCost-Benefit AnalysisDietary ProteinsDietary SupplementsFemaleGastrointestinal DiseasesHumansMaleMalnutritionMiddle AgedNutrition TherapyPilot ProjectsDietary Proteins

Identifiers

PMID21407248
OpenAlexW2159869190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.