ReviewNature reviews. Microbiology2011
Unravelling the effects of the environment and host genotype on the gut microbiome.
Review in Nature reviews. Microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 745 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
745 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Mother-to-infant vertical transmission in early life: a systematic review and proportional meta-analysis of Bifidobacterium strain transmissibility.NPJ biofilms and microbiomes · 2025Pooled it
- Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach.Journal of health, population, and nutrition · 2025Pooled it
- Association of gastrointestinal microbiome and obesity with gestational diabetes mellitus-an updated globally based review of the high-quality literatures.Nutrition & diabetes · 2024Pooled it
- Diet, Microbes, and Cancer Across the Tree of Life: a Systematic Review.Current nutrition reports · 2022Pooled it
- Comparative pathogenicity of Ma5 vaccine and a field isolate of the avian infectious bronchitis virus in SPF chickens.Poultry science · 2026Article
- Is a Commensal Here, a Pathogen There? Genotype Specific Responses by the Sea Anemone Nematostella vectensis to Vibrio Species.Molecular ecology · 2026Article
- Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin deficient mice.EMBO molecular medicine · 2026Article
- RNA in Plasma Extracellular Vesicles of Adolescent Rhesus Macaques Reveals Immune, Bioenergetic, and Microbial Imprints of Early-Life Adversity: An Exploratory Analysis.Biological psychiatry · 2026Article
- Consistent, Scale-Dependent Differences in the Biogeography of Host-Associated and Free-Living Microbiomes Across Systems.Molecular ecology · 2026Article
- Gut Modulators Alter BDNF/Cortisol Axis in Severe Obesity: Additional Secondary Outcomes from a Triple-Blind Randomized Trial.Life (Basel, Switzerland) · 2026Article
- The root rhizosphere as a functional analog to the gut microbiome: Cases for microbial symbiosis and dysbiosis in parallel contexts.PNAS nexus · 2026Review
- Microbiome modulating remedies for chronic diseases: a review of current interventions and future directions.Inflammopharmacology · 2026Review
- Functional traits shape gut microbial assembly beyond phylogeny in estuarine fish.Science China. Life sciences · 2026Article
- MHC class II genes influence the gut microbiota of wild golden snub-nosed monkeys.BMC microbiology · 2026Article
- Insights into pig resilience: the Microbiome-genetic connection.Porcine health management · 2026Review
- From Womb to Weaning: Microbial Signals That Shape the Developing Brain.Developmental neuroscience · 2026Review
- Host genomic regulation of ileal Bradyrhizobium abundance modulates eating speed and fat metabolism in birds: a causal mechanism study.Journal of animal science and biotechnology · 2026Article
- From association to intervention: Muribaculaceae driven SCFAs production enhances boar semen quality via inflammation alleviation.NPJ biofilms and microbiomes · 2026Article
- Cluster dispersal shapes microbial diversity during community assembly.PLoS computational biology · 2026Article
- Article
685 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
To what extent do host genetics control the composition of the gut microbiome? Studies comparing the gut microbiota in human twins and across inbred mouse lines have yielded inconsistent answers to this question. However, candidate gene approaches, in which one gene is deleted or added to a model host organism, show that a single host gene can have a tremendous effect on the diversity and population structure of the gut microbiota. Now, quantitative genetics is emerging as a highly promising approach that can be used to better understand the overall architecture of host genetic influence on the microbiota, and to discover additional host genes controlling microbial diversity in the gut. In this Review, we describe how host genetics and the environment shape the microbiota, and how these three factors may interact in the context of chronic disease.
Indexed as
Identifiers
21407244What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.