Evidence map›Paper›PMID 21407243›Full record

ReviewNature reviews. Microbiology2011

Mucin dynamics and enteric pathogens.

Michael A McGuckin, Sara K Lindén, Philip Sutton, Timothy H Florin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 708 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
708citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

708 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026
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  17. Low-Molecular-Weight Fucoidan fromFoods (Basel, Switzerland) · 2026
    Article
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  20. Review

648 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael A McGuckinImmunity, Infection and Inflammation Program, Mater Medical Research Institute and The University of Queensland School of Medicine, South Brisbane, Queensland 4101, Australia. mmcguckin@mmri.mater.org.au
Sara K Lindén
Philip Sutton
Timothy H Florin

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extracellular secreted mucus and the cell surface glycocalyx prevent infection by the vast numbers of microorganisms that live in the healthy gut. Mucin glycoproteins are the major component of these barriers. In this Review, we describe the components of the secreted and cell surface mucosal barriers and the evidence that they form an effective barricade against potential pathogens. However, successful enteric pathogens have evolved strategies to circumvent these barriers. We discuss the interactions between enteric pathogens and mucins, and the mechanisms that these pathogens use to disrupt and avoid mucosal barriers. In addition, we describe dynamic alterations in the mucin barrier that are driven by host innate and adaptive immune responses to infection.

Indexed as

Bacterial InfectionsGastric MucosaGastrointestinal DiseasesGastrointestinal TractIntestinal MucosaMucinsAdaptive ImmunityAnimalsGlycocalyxGoblet CellsHumansImmunity, InnateMucusPaneth CellsMucins

Identifiers

PMID21407243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.