ArticleMolecular systems biology2011
Adapt locally and act globally: strategy to maintain high chemoreceptor sensitivity in complex environments.
Article in Molecular systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Time-reversal symmetry breaking in the chemosensory array reveals a general mechanism for dissipation-enhanced cooperative sensing.Nature communications · 2024Article
- Signal integration and adaptive sensory diversity tuning in Escherichia coli chemotaxis.Cell systems · 2024Article
- Flagellar dynamics reveal fluctuations and kinetic limit in the Escherichia coli chemotaxis network.Scientific reports · 2023Article
- Article
- Bacterial chemotaxis to saccharides is governed by a trade-off between sensing and uptake.Biophysical journal · 2022Article
- Sequential modification of bacterial chemoreceptors is key for achieving both accurate adaptation and high gain.Nature communications · 2020Article
- Regulation of the chemotaxis histidine kinase CheA: A structural perspective.Biochimica et biophysica acta. Biomembranes · 2020Review
- Decoding the chemotactic signal.Journal of leukocyte biology · 2018Review
- Behavioral Variability and Phenotypic Diversity in Bacterial Chemotaxis.Annual review of biophysics · 2018Review
- Mathematical Analysis of the Escherichia coli Chemotaxis Signalling Pathway.Bulletin of mathematical biology · 2018Article
- Motor Adaptive Remodeling Speeds Up Bacterial Chemotactic Adaptation.Biophysical journal · 2018Article
- Global landscape of cell envelope protein complexes in Escherichia coli.Nature biotechnology · 2018Article
- Mechanism of bidirectional thermotaxis ineLife · 2017Article
- Information processing in bacteria: memory, computation, and statistical physics: a key issues review.Reports on progress in physics. Physical Society (Great Britain) · 2016Review
- Protein Connectivity in Chemotaxis Receptor Complexes.PLoS computational biology · 2015Article
- Bacterial chemoreceptors and chemoeffectors.Cellular and molecular life sciences : CMLS · 2015Review
- Universal response-adaptation relation in bacterial chemotaxis.Journal of bacteriology · 2015Article
- An O-Methyltransferase Is Required for Infection of Tick Cells by Anaplasma phagocytophilum.PLoS pathogens · 2015Article
- The role of membrane-mediated interactions in the assembly and architecture of chemoreceptor lattices.PLoS computational biology · 2014Article
- Behaviors and strategies of bacterial navigation in chemical and nonchemical gradients.PLoS computational biology · 2014Article
Corrections and comments
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4 authors.
Funding
Abstract
In bacterial chemotaxis, several types of ligand-specific receptors form mixed clusters, wherein receptor-receptor interactions lead to signal amplification and integration. However, it remains unclear how a mixed receptor cluster adapts to individual stimuli and whether it can differentiate between different types of ligands. Here, we combine theoretical modeling with experiments to reveal the adaptation dynamics of the mixed chemoreceptor cluster in Escherichia coli. We show that adaptation occurs locally and is ligand-specific: only the receptor that binds the external ligand changes its methylation level when the system adapts, whereas other types of receptors change methylation levels transiently. Permanent methylation crosstalk occurs when the system fails to adapt accurately. This local adaptation mechanism enables cells to differentiate individual stimuli by encoding them into the methylation levels of corresponding types of chemoreceptors. It tunes each receptor to its most responsive state to maintain high sensitivity in complex environments and prevents saturation of the cluster by one signal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.