ArticleNature communications2011
A C2 domain protein kinase initiates phagocytosis in the protozoan parasite Entamoeba histolytica.
Article in Nature communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Dynamic Association of ESCRT-II Proteins with ESCRT-I and ESCRT-III Complexes during Phagocytosis ofInternational journal of molecular sciences · 2023Article
- An atypical EhGEF regulates phagocytosis in Entamoeba histolytica through EhRho1.PLoS pathogens · 2021Article
- Trogocytosis in Unicellular Eukaryotes.Cells · 2021Review
- Rab7D small GTPase is involved in phago-, trogocytosis and cytoskeletal reorganization in the enteric protozoan Entamoeba histolytica.Cellular microbiology · 2021Article
- The Multiple Roles of Trogocytosis in Immunity, the Nervous System, and Development.BioMed research international · 2021Review
- Structural and functional diversity of Entamoeba histolytica calcium-binding proteins.Biophysical reviews · 2020Review
- Rab GTPases take centre stage in understandingSmall GTPases · 2020Review
- EhC2B, a C2 domain-containing protein, promotes erythrophagocytosis in Entamoeba histolytica via actin nucleation.PLoS pathogens · 2020Article
- Entamoeba histolytica and pathogenesis: A calcium connection.PLoS pathogens · 2020Review
- Uncovering the Cyclic AMP Signaling Pathway of the Protozoan ParasiteFrontiers in cellular and infection microbiology · 2020Article
- Revisiting Drug Development Against the Neglected Tropical Disease, Amebiasis.Frontiers in cellular and infection microbiology · 2020Review
- EhP3, a homolog of 14-3-3 family of protein participates in actin reorganization and phagocytosis in Entamoeba histolytica.PLoS pathogens · 2019Article
- Tissue Destruction Caused byCurrent clinical microbiology reports · 2019Review
- Stress-induced nuclear depletion ofThe Journal of biological chemistry · 2018Article
- AGC family kinase 1 participates in trogocytosis but not in phagocytosis in Entamoeba histolytica.Nature communications · 2017Article
- The Monomeric GTPase Rab35 Regulates Phagocytic Cup Formation and Phagosomal Maturation inThe Journal of biological chemistry · 2017Article
- Entamoeba histolytica: Host parasite interactions at the colonic epithelium.Tissue barriers · 2017Article
- Identification of the phospholipid lysobisphosphatidic acid in the protozoanBiochemistry and biophysics reports · 2016Article
- Autophosphorylation at Thr279 of Entamoeba histolytica atypical kinase EhAK1 is required for activity and regulation of erythrophagocytosis.Scientific reports · 2016Article
- Immune Response of Amebiasis and Immune Evasion by Entamoeba histolytica.Frontiers in immunology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phagocytosis is a process whereby particles are taken in by cells through mechanisms superficially similar to those for endocytosis. It serves a wide range of functions, from providing nutrition in unicellular organisms to initiation of both innate and adaptive immunity in vertebrates. In the protozoan parasite Entamoeba histolytica, it has an essential role in survival and pathogenesis. In this study, we show that EhC2PK, a C2-domain-containing protein kinase, and the Ca²(+) and actin-binding protein, EhCaBP1, are involved in the initiation of phagocytosis in E. histolytica. Conditional suppression of EhC2PK expression and overexpression of a mutant form reveals its role in the initiation of phagocytic cups. EhC2PK binds phosphatidylserine in the presence of Ca²(+) and thereby recruits EhCaBP1 and actin to the membrane. Identification of these proteins in phagocytosis is an important step in amoebic biology and these molecules could be the important targets for developing novel therapies against amoebiasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.