ArticleGenetics in medicine : official journal of the American College of Medical Genetics2011
Informed consent to microsatellite instability and immunohistochemistry screening for Lynch syndrome.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Universal screening of colorectal tumors for lynch syndrome: a survey of patient experiences and opinions.Hereditary cancer in clinical practice · 2024Article
- Universal tumor screening for lynch syndrome on colorectal cancer biopsies impacts surgical treatment decisions.Familial cancer · 2023Article
- Effective Identification of Lynch Syndrome in Gastroenterology Practice.Current treatment options in gastroenterology · 2019Review
- Universal tumor screening for Lynch syndrome: perspectives of Canadian pathologists and genetic counselors.Journal of community genetics · 2019Article
- Universal Screening of Colorectal Cancers for Lynch Syndrome: Challenges and Opportunities.Digestive diseases and sciences · 2016Review
- Selective Versus Universal Screening for Lynch Syndrome: A Six-Year Clinical Experience.Digestive diseases and sciences · 2015Article
- A single institution experience in compliance with universal screening for Lynch syndrome in colorectal cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Article
- Relationship between MLH-1, MSH-2, PMS-2,MSH-6 expression and clinicopathological features in colorectal cancer.International journal of clinical and experimental pathology · 2015Article
- Current Lynch syndrome tumor screening practices: a survey of genetic counselors.Journal of genetic counseling · 2014Article
- The genetic basis of Lynch syndrome and its implications for clinical practice and risk management.The application of clinical genetics · 2014Review
- Implementation of universal microsatellite instability and immunohistochemistry screening for diagnosing lynch syndrome in a large academic medical center.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Article
- Can a gastrointestinal pathologist identify microsatellite instability in colorectal cancer with reproducibility and a high degree of specificity?Familial cancer · 2012Article
- Reflex immunohistochemistry and microsatellite instability testing of colorectal tumors for Lynch syndrome among US cancer programs and follow-up of abnormal results.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Article
- Implementing screening for Lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting.Genetics in medicine : official journal of the American College of Medical Genetics · 2012Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveRoutine microsatellite instability and immunohistochemistry screening of colorectal cancers can assist in identifying a significant proportion of cancers attributable to Lynch syndrome. This article considers whether it is necessary to obtain patient informed consent for microsatellite instability and immunohistochemistry screening.
resultsAlthough microsatellite instability screening examines genetic features of a tumor, it lacks several important characteristics that typically mandate formal informed consent to genetic testing. Microsatellite instability screening describes discrete tissue samples and does not provide information about the rest of the patient's body or germline. In contrast, immunohistochemistry screening is a proteomic test that may reveal information about the patient's germline. As such, immunohistochemistry screening can be viewed as similar to other forms of genetic testing, in which explicit patient consent is regarded as an ethical prerequisite.
conclusionThere is no ethical requirement to obtain explicit informed consent for microsatellite instability screening of colorectal tumor samples for Lynch syndrome. There is support for obtaining patient consent to immunohistochemistry testing, given its similarities with other genetic analyses for which informed consent is typically deemed necessary. Regardless of which screening test is used, it is important to prepare patients and their families for the possibility of a positive screening test.
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