ArticleJournal of acquired immune deficiency syndromes (1999)2010
Antiretroviral therapy: a promising HIV prevention strategy?
Article in Journal of acquired immune deficiency syndromes (1999), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01152918 (TLC-Plus), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TLC-Plus: A Study to Evaluate the Feasibility of an Enhanced Test, Link to Care, Plus Treat Approach for HIV Prevention in the United States
Who cites it
15 citing papers in PubMed.
- Failure to return to receive HIV-test results: the Cameroon experience.BMC research notes · 2017Article
- Latent class profiles of internalizing and externalizing psychosocial health indicators are differentially associated with sexual transmission risk: Findings from the CFAR network of integrated clinical systems (CNICS) cohort study of HIV-infected men engaged in primary care in the United States.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2015Article
- Recruitment and ethical considerations in HIV cure trials requiring treatment interruption.Journal of virus eradication · 2015Article
- Using HIV surveillance registry data to re-link persons to care: the RSVP Project in San Francisco.PloS one · 2015Article
- Article
- Substance use among HIV-infected patients engaged in primary care in the United States: findings from the Centers for AIDS Research Network of Integrated Clinical Systems cohort.American journal of public health · 2013Article
- mHealth for HIV Treatment & Prevention: A Systematic Review of the Literature.The open AIDS journal · 2013Article
- Routine HIV testing among hospitalized patients in Argentina. is it time for a policy change?PloS one · 2013Observational
- Clinician practices and attitudes regarding early antiretroviral therapy in the United States.Journal of acquired immune deficiency syndromes (1999) · 2012Article
- Projecting the benefits of antiretroviral therapy for HIV prevention: the impact of population mobility and linkage to care.The Journal of infectious diseases · 2012Article
- HIV transmission rate modeling: a primer, review, and extension.AIDS and behavior · 2012Review
- Universal access to HIV treatment versus universal 'test and treat': transmission, drug resistance & treatment costs.PloS one · 2012Article
- Article
- Conceptual framework for behavioral and social science in HIV vaccine clinical research.Vaccine · 2011Article
- Retention in care within 1 year of initial HIV care visit in a multisite US cohort: who's in and who's out?Journal of the International Association of Providers of AIDS CareObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The use of antiretroviral therapy (ART) has been associated with significant improvement in morbidity and survival of persons living with HIV. In addition, recently, there has also been intense interest in the potential impact of ART on HIV transmission and consequently on the trajectory of the HIV epidemic globally. Evidence from mathematical modeling analyses and observational and ecological studies supports the potential for ART as prevention. However, definitive data from clinical trials are awaited. In the United States, the feasibility and potential of using ART as a prevention strategy presents particular challenges: the large number of individuals with undiagnosed HIV; the predominance of disenfranchised individuals affected by the epidemic; evidence of delay in engagement in HIV care after diagnosis with attendant late initiation of ART; and difficulties with consistent long-term adherence to ART and concerns regarding long-term risk-behavior change. Thus, for this novel effort to succeed, a multidimensional approach is necessary that must include policy changes, social mobilization, and improved access to clinical and supportive services for persons living with HIV, with a particular focus on the unique needs of at-risk populations, combined with engagement of all cadres of health care providers and community constituencies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.