ArticleFly
Modularity of CHIP/LDB transcription complexes regulates cell differentiation.
Article in Fly. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome.Nature communications · 2023Article
- Human ERG oncoprotein repressesProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Roles of the LIM Domain Proteins inFrontiers in cardiovascular medicine · 2021Review
- SEUSS integrates transcriptional and epigenetic control of root stem cell organizer specification.The EMBO journal · 2020Article
- Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models.Nature communications · 2019Article
- SEUSS Integrates Gibberellin Signaling with Transcriptional Inputs from the SHR-SCR-SCL3 Module to Regulate Middle Cortex Formation in the Arabidopsis Root.Plant physiology · 2016Article
- Article
- Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Transcription is the first step through which the cell operates, via its repertoire of transcription complexes, to direct cellular functions and cellular identity by generating the cell-specific transcriptome. The modularity of the composition of constituents of these complexes allows the cell to delicately regulate its transcriptome. In a recent study we have examined the effects of reducing the levels of specific transcription co-factors on the function of two competing transcription complexes, namely CHIP-AP and CHIP-PNR which regulate development of cells in the thorax of Drosophila. We found that changing the availability of these co-factors can shift the balance between these complexes leading to transition from utilization of CHIP-AP to CHIP-PNR. This is reflected in change in the expression profile of target genes, altering developmental cell fates. We propose that such a mechanism may operate in normal fly development. Transcription complexes analogous to CHIP-AP and CHIP-PNR exist in mammals and we discuss how such a shift in the balance between them may operate in normal mammalian development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.