Evidence map›Paper›PMID 21406610›Full record

Trial reportJournal of dental research2011

Saliva/pathogen biomarker signatures and periodontal disease progression.

J S Kinney, T Morelli, T Braun, C A Ramseier, A E Herr, J V Sugai, C E Shelburne, L A Rayburn, A K Singh, W V Giannobile

Erratum issued 3 registry-linked trialsAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 104 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 7 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00277745 completednot on this map

Integrated Microfluidic System for Oral Diagnostics

TypeobservationalSponsorUniversity of MichiganRan2005 to 2007Enrolled100ConditionsHealthy, PeriodontitisArmsminiaturized microfluidic system
NCT04605289 phase1 / phase2completednot on this mapstarted 2020, after this paper: background citation

Biochemical Efficacy of Cymbopogon Citratus Gel as Local Drug Delivery Agent in Reducing Matrix Metalloproteinase-8 Levels Intra-crevicularly in Moderate Periodontitis Patients

TypeinterventionalSponsorAlexandria UniversityRan2020 to 2020Enrolled40ConditionsPeriodontitisArmslemongrass essential oil gel, Placebo, Scaling and root planing
NCT07661784 recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of Salivary Biomarkers Associated With Bone Remodeling in the Transition From Periodontal Health to Disease

TypeobservationalSponsorSuleyman Demirel UniversityRan2025 to 2026Enrolled240ConditionsPeriodontal Disease, Gingivitis and Periodontal Diseases, PeriodontitisArmsSaliva Sampling
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 7 syntheses or guidelines pooled it, 215 citations in OpenAlex.

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  13. Impact of asthma and its treatment on periodontal and oral health in Moroccan children.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  14. Review
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

J S KinneyDepartment of Periodontics and Oral Medicine, Michigan Center for Oral Health Research, University of Michigan School of Dentistry, 24 Frank Lloyd Wright Dr., Lobby M, Box 422, Ann Arbor, MI 48106 USA.
T Morelli
T Braun
C A Ramseier
A E Herr
J V Sugai
C E Shelburne
L A Rayburn
A K Singh
W V Giannobile
University of Michigan–Ann Arbor · USSandia National Laboratories California · USUniversity of California, Berkeley · US

Funding

ZINC GLUCONATE GLYCINE LOZENGES &VITAMIN C EFFECTS ON COMMON COLDM01RR000042 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUBENFIRE, MELVYN · 1985 to 2007
$40.8M
Integrated Microfluidic System for Oral DiagnosticsU01DE014961 · NIDCR · SANDIA CORP-SANDIA NATIONAL LABORATORIES · PI SINGH, ANUP K · 2002 to 2005
$4.2M
NCRR NIH HHS M01 RR000042NIDCR NIH HHS U01 DE014961NIDCR NIH HHS U01-DE014961PHS HHS ULRR000042
6 · The paper itself

Abstract

The purpose of this study was to determine the role of saliva-derived biomarkers and periodontal pathogens during periodontal disease progression (PDP). One hundred human participants were recruited into a 12-month investigation. They were seen bi-monthly for saliva and clinical measures and bi-annually for subtraction radiography, serum and plaque biofilm assessments. Saliva and serum were analyzed with protein arrays for 14 pro-inflammatory and bone turnover markers, while qPCR was used for detection of biofilm. A hierarchical clustering algorithm was used to group study participants based on clinical, microbiological, salivary/serum biomarkers, and PDP. Eighty-three individuals completed the six-month monitoring phase, with 39 [corrected] exhibiting PDP, while 44 [corrected] demonstrated stability. Participants assembled into three clusters based on periodontal pathogens, serum and salivary biomarkers. Cluster 1 members displayed high salivary biomarkers and biofilm; 71% [corrected] of these individuals were undergoing PDP. Cluster 2 members displayed low biofilm and biomarker levels; 76% [corrected] of these individuals were stable. Cluster 3 members were not discriminated by PDP status; however, cluster stratification followed groups 1 and 2 based on thresholds of salivary biomarkers and biofilm pathogens. The association of cluster membership to PDP was highly significant (p < 0.0007). [corrected] The use of salivary and biofilm biomarkers offers potential for the identification of PDP or stability (ClinicalTrials.gov number, CT00277745).

Indexed as

Bacterial Typing TechniquesBiofilmsBiomarkersChi-Square DistributionChronic PeriodontitisCluster AnalysisDental PlaqueDisease ProgressionDNA, BacterialFemaleGingivaGingivitisHumansLinear ModelsMaleMiddle AgedBiomarkersDNA, Bacterial

Identifiers

PMID21406610
PMCPMC3144122
OpenAlexW2166779211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.